{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:40:41Z","timestamp":1789486841197,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This systematic review evaluates oxidative stress markers (OSM) in acute pancreatitis (AP) and their role in predicting AP severity and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational studies evaluating OSM in adults with AP were identified through systematic searches of PubMed, Embase, Web of Science and Cochrane Library from database inception to the final search date, with no date restrictions owing to limited available literature. Studies in all languages were initially screened, but only those with accessible English full texts were eligible for inclusion. Study selection, data extraction and quality assessment were performed independently by two reviewers. Differences in AP severity definitions were recorded and considered during analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen prospective observational studies (1998\u20132023) evaluated oxidative stress and antioxidant biomarkers in adults with acute pancreatitis. Across studies, OSMs were consistently elevated in AP and increased further with disease severity. Lipid peroxidation products and reactive oxygen species, including malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), superoxide radicals and thioredoxin\u20101 (TRX\u20101), were significantly higher in severe AP (SAP) and correlated with systemic complications and CT severity scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007 to\u00a0&lt;\u00a00.010). In contrast, antioxidant defences were reduced in SAP, with lower levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), ascorbic acid and transferrin sialylation levels associated with persistent organ failure, mortality and increased inflammatory burden (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005 to\u00a0&lt;\u00a00.001). The oxidative stress index (OSI) correlated with 48\u2010h Ranson scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.027), reflecting a systemic pro\u2010oxidant state. Emerging biomarkers, including oleic acid chlorohydrin (OAC), intestinal fatty acid\u2010binding protein (I\u2010FABP), ischemia\u2010modified albumin (IMA), and the GSTT\u20101*A polymorphism, also demonstrated prognostic value for disease severity and progression (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005 to\u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oxidative stress and impaired antioxidant defences are consistently associated with increasing AP severity and adverse clinical outcomes. Several biomarkers demonstrate potential for early risk stratification. Although antioxidant therapies have previously been evaluated in AP, current findings remain heterogeneous and insufficient to establish clinical benefit, warranting further high\u2010quality studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70499","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:50:36Z","timestamp":1783921836000},"page":"2586-2599","source":"Crossref","is-referenced-by-count":0,"title":["Systematic Review of Role of Oxidative Stress and Clinical Implications in Acute Pancreatitis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-5970","authenticated-orcid":false,"given":"Shantata","family":"Kudchadkar","sequence":"first","affiliation":[{"name":"Department of HPB and Transplant Surgery Freeman Hospital  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Peddakota","sequence":"additional","affiliation":[{"name":"Department of HPB and Transplant Surgery Freeman Hospital  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litesh Chouhan","family":"Mudavath","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-2197","authenticated-orcid":false,"given":"Sanjay","family":"Pandanaboyana","sequence":"additional","affiliation":[{"name":"Department of HPB and Transplant Surgery Freeman Hospital  Newcastle Upon Tyne UK"},{"name":"Population Health Sciences Institute Newcastle University  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.043"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2025.02.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010021\u201001906\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae170"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000000755"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100158\u20102"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000001135"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12464"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"185","article-title":"Malondialdehyde and Superoxide Dismutase as Potential Markers of Severity in Acute Pancreatitis","volume":"7","author":"Abu\u2010Hilal M.","year":"2006","journal-title":"JOP"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2000.01464.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1999.01182.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010017\u20100346\u20106"},{"issue":"10","key":"e_1_2_10_16_1","first-page":"10552","article-title":"Prognostic Significance of Ischemia\u2010Modified Albumin for Severe Acute Pancreatitis","volume":"10","author":"Du X. 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