{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:14Z","timestamp":1790611694321,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute appendicitis is a common surgical emergency. The optimal time\u2010to\u2010surgery interval remains debated, as studies reported increased complication risk beyond 12 or 24\u00a0hours respectively. We hypothesized that time\u2010to\u2010surgery of up to 24\u00a0hours after admission was not associated with increased postoperative length of stay (LOS) or complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational cohort study included adults and adolescents (\u2265 15\u00a0years) undergoing laparoscopic appendectomy from January 2017\u2013July 2025 in the Capital and the Zealand Regions of Denmark. Data were extracted from the Electronic Health Record system. The primary exposure was time\u2010to\u2010surgery intervals. Primary outcome was postoperative LOS. Secondary outcomes were 30\u2010day postoperative complications. Subgroup analyses were performed for uncomplicated\/complicated appendicitis. All outcomes were evaluated by multivariable regression models adjusted for predefined confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 25,417 laparoscopic appendectomies, 19,089 met eligibility criteria. Compared with time\u2010to\u2010surgery &lt; 8\u00a0hours, postoperative LOS was reduced when time\u2010to\u2010surgery was 8\u201316\u00a0hours (mean difference \u22122.29\u00a0hours, 95% CI: \u22123.85 to \u22120.73) and 16\u201324\u00a0hours (\u22123.92\u00a0hours, 95% CI: \u22126.05 to \u22121.78). Compared with time\u2010to\u2010surgery &lt; 8\u00a0hours, odds of postoperative complications were reduced for time\u2010to\u2010surgery up to 24\u00a0hours, whereas \u2265 36\u00a0hours was associated with increased odds (OR 1.57, 95% CI: 1.13 to 2.18). In complicated appendicitis, time\u2010to\u2010surgery 24\u201336\u00a0hours was associated with decreased postoperative LOS (\u221213.0\u00a0hours, 95% CI: \u221222 to \u22123.6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Time\u2010to\u2010surgery of up to 24\u00a0hours was not associated with increased postoperative LOS or complications. In contrast, we observed a protective association driven by complicated appendicitis, potentially reflecting effective clinical triage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70506","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:07:51Z","timestamp":1786018071000},"page":"2609-2624","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Time\u2010To\u2010Surgery and Postoperative Length of Stay and Complications in Patients With Acute Appendicitis"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2942-140X","authenticated-orcid":false,"given":"Anne Haff","family":"Jepsen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d 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Zealand  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0551-7223","authenticated-orcid":false,"given":"Rikke Helene","family":"Fr\u00f8lund Bjulf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7069-9767","authenticated-orcid":false,"given":"Aurelien\u2010Xuan R.","family":"Bahuet","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6337-8447","authenticated-orcid":false,"given":"Claus Anders","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Department of Surgery Copenhagen University Hospital\u2013North Zealand  Hiller\u00f8d Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-5888","authenticated-orcid":false,"given":"Kai Henrik","family":"Wiborg Lange","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Copenhagen University Hospital \u2013 North Zealand  Hiller\u00f8d Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-3751","authenticated-orcid":false,"given":"Anders Peder","family":"H\u00f8jer Karlsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Anesthesiology and Intensive Care Medicine Copenhagen 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