{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:40:37Z","timestamp":1789486837036,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ISCIII (CM24\/00019)"],"award-info":[{"award-number":["ISCIII (CM24\/00019)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Medullary thyroid cancer (MTC) is an aggressive tumor for which surgery is the only curative treatment. However, after surgery, some patients may experience persistence\/recurrence. It is important to identify the prognostic factors that may affect structural disease\u2010free survival (SDFS), which may influence the follow\u2010up of our patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess SDFS in patients with MTC and related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective observational study was conducted in a tertiary hospital including patients with MTC without distant metastases. The following variables were assessed: sex, age, heritability, type of surgery, calcitonin (Ct) and CEA, tumor size, stage, lymph nodes ratio (LNR), vascular invasion, high risk, structural disease, and SDFS. A descriptive and comparative univariate and multivariate analysis of SDFS was performed using SPSS version.29 and Cox regression, defining structural disease as the event.\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 140 patients with a median age of 34\u00a0years were evaluated. Forty\u2010six percent (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a065) were male. Twenty\u2010two percent (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031) had sporadic MTC, 75% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0106) had MEN2a, and 2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) had MEN2b. The median calcitonin level was 182.5pg\/mL and median follow\u2010up was 179.5\u00a0months. Structural disease occurred in 24% of patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033). The variables that influenced the SDFS were as follows: sporadic CMT, older age, preoperative CEA, size, lymph node involvement, higher LNR, vascular invasion and high risk, and Ct levels &gt; 150pg\/mL at 6\u201312\u00a0months. In the multivariate analysis, age, LNR, T category, and postoperative Ct remained independent predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SDFS in MTC is significantly influenced by LNR, T category, and postoperative Ct levels at 6\u201312\u00a0months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70524","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:40:36Z","timestamp":1786182036000},"page":"2662-2668","source":"Crossref","is-referenced-by-count":0,"title":["Predicting Structural Progression\u2010Free Survival After Surgery for Medullary Thyroid Carcinoma"],"prefix":"10.1002","volume":"50","author":[{"given":"I.","family":"Ros\u2010Madrid","sequence":"first","affiliation":[{"name":"Endocrinology Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria Pascual Parrilla (IMIB Pascual Parrilla)  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-2147","authenticated-orcid":false,"given":"B.","family":"Febrero","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria Pascual Parrilla (IMIB Pascual Parrilla)  Murcia Spain"},{"name":"Endocrine Surgery Unit General Surgery Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"},{"name":"Deparment of Surgery University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Cano\u2010M\u00e1rmol","sequence":"additional","affiliation":[{"name":"Endocrinology Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Segura","sequence":"additional","affiliation":[{"name":"Endocrinology Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Endocrinology Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria Pascual Parrilla (IMIB Pascual Parrilla)  Murcia Spain"},{"name":"Endocrine Surgery Unit General Surgery Service Virgen de la Arrixaca University Clinical Hospital  Murcia Spain"},{"name":"Deparment of Surgery University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201022542\u20105_3"},{"key":"e_1_2_12_3_1","first-page":"139","article-title":"Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974\u20132013 Hyeyeun","volume":"176","author":"Lim H.","year":"2017","journal-title":"Physiology & Behavior"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0167"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27181"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225842"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4158\/ep161684.or"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.749973"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338221078435"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359\u20103997000000209"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2006.02659.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010018\u20104738\u2010z"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"S627","article-title":"Medullary Thyroid Carcinoma: Prognostic Variables and Tumour Markers Affecting Survival","volume":"30","author":"Hassan A.","year":"2018","journal-title":"Journal of Ayub Medical College, Abbottabad"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15025"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.11.009"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15141"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010023\u201003328\u20104"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600930"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3094642"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.04.016"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201022\u20102737"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.4158\/ep\u20102019\u20100404"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad061"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010022\u201002591\u20109"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8888677"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2016.91.6.278"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab326"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.09.002"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17193193"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010010\u20101021\u20104"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70524","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:23:39Z","timestamp":1789478619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,8]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/wjs.70524"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70524","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,8]]}}}