{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:46:18Z","timestamp":1791963978886,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While whole blood (WB) is increasingly utilized to mitigate trauma\u2010induced coagulopathy, evidence supporting its use in blunt trauma\u2013associated prehospital cardiac arrest (PHCA) remains scarce. We compared the association of WB versus component therapy (CT) with mortality and early resuscitation balance among patients who achieved return of spontaneous circulation (ROSC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used National Trauma Data Bank data from 2020 through 2024. Adults aged 16\u00a0years or older with blunt trauma, documented PHCA, a nonzero initial emergency department systolic blood pressure, survival beyond 1\u00a0hour after arrival, and receipt of at least 1 unit of WB or red blood cells within 4\u00a0hours were included. Propensity score overlap weighting balanced measured baseline characteristics. A prespecified 2\u2010h landmark sensitivity analysis evaluated robustness among early survivors, and restricted cubic spline interaction models assessed heterogeneity across Injury Severity Score (ISS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3472 patients, 995 (28.7%) received WB. Unadjusted 30\u2010day in\u2010hospital mortality was 69.9% with WB and 72.6% with component therapy; weighted estimated mortality was 69.7% and 72.2%, respectively (hazard ratio, 0.89; 95% CI, 0.81\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Findings were similar in the 2\u2010h landmark analysis (hazard ratio, 0.88; 95% CI, 0.80\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). At similar total transfusion volumes, WB transfusion delivered greater calculated platelet (mean ratio, 1.40; 95% CI, 1.27\u20131.55) and plasma equivalents (mean ratio, 1.21; 95% CI, 1.10\u20131.33); 55.4% of component\u2010therapy recipients received no platelets within 4\u00a0hours. The association with lower mortality was more pronounced at higher ISS values (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among selected early survivors of blunt traumatic PHCA with restored circulation during initial hospital assessment, WB transfusion was associated with lower 30\u2010day in\u2010hospital mortality and greater calculated plasma and platelet delivery than component\u2010only therapy. Residual confounding and survivor selection remain possible, and prospective confirmation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70563","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:49:37Z","timestamp":1788331777000},"page":"3092-3102","source":"Crossref","is-referenced-by-count":0,"title":["Association of Whole Blood Transfusion With Survival Among Patients Achieving ROSC After Prehospital Traumatic Cardiac Arrest"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-4103","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Division of Trauma and Acute Care Surgery Department of Surgery Los Angeles General Medical Center  Los Angeles California USA"},{"name":"Department of Trauma Surgery Chongqing University Central Hospital Chongqing Emergency Medical Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-9734","authenticated-orcid":false,"given":"Caitlyn","family":"Braschi","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery Department of Surgery Los Angeles General Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-7771","authenticated-orcid":false,"given":"Meghan R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery Department of Surgery Los Angeles General Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Demetriades","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery Department of Surgery Los Angeles General Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068\u2010022\u201001941\u2010y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed\u20102021\u2010211723"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.04.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373\u2010199502000\u201000006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14062111"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000264\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004562"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18143"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010024\u201005041\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2023.7178"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004382"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006150"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004438"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006316"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005251"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000708"},{"key":"e_1_2_11_18_1","unstructured":"American Association of Blood Banks \u201cCircular of Information for the Use of Human Blood and Blood Components \u201d accessed October 25 2025 https:\/\/www.aabb.org\/news\u2010resources\/resources\/circular\u2010of\u2010information."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12798"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7819"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010017\u20100445\u2010y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2516043"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004327"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002315"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16528"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.318801"},{"key":"e_1_2_11_28_1","doi-asserted-by":"crossref","unstructured":"C. C.McCoy B. A.Cotton M.Brenner et\u00a0al. \u201cBack to the Future: Whole Blood Resuscitation of the Severely Injured Trauma Patient \u201d Shock Publish Ahead of Print9(2020) https:\/\/doi.org\/10.1097\/SHK.0000000000001685.","DOI":"10.1097\/SHK.0000000000001685"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102215\u20108936"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003027"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16965"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31819d85fb"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob\u201020\u201030"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40719\u2010022\u201000236\u20102"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005603"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004378"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000086"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004429"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005982"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000006317"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018017699"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010022\u201003928\u2010y"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2024.115887"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70563","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:01:11Z","timestamp":1791961271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/wjs.70563"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70563","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}