{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:53:12Z","timestamp":1791121992283,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The CRASH\u20102 regimen for tranexamic acid (TXA) consists of a 1\u2010g intravenous bolus followed by a 1\u2010g infusion over 8\u00a0hours. The maintenance infusion may be challenging to administer during the early phase of trauma resuscitation. We compared mortality outcomes between patients receiving a 1\u2010g TXA bolus alone and those receiving a bolus\u2010plus\u2010infusion regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of adult trauma patients (\u2265\u00a019\u00a0years) who presented directly to the trauma bay at a regional trauma center between July 2018 and December 2023. Patients who received TXA within 3\u00a0hours of injury were included in the inter\u2010regimen analysis and categorized into either a 1\u2010g bolus\u2010only group or a 1\u2010g bolus plus 1\u2010g infusion group. Clinical outcomes were compared using multivariable logistic regression. To minimize selection bias and baseline imbalances, 1:1 propensity score matching was performed, followed by McNemar testing and conditional logistic regression analyses in the matched cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 5204 eligible patients, 1787 received TXA. The primary inter\u2010regimen cohort included 1408 patients treated within 3\u00a0hours of injury: 409 received bolus\u2010only TXA and 999 received bolus\u2010plus\u2010infusion TXA. Propensity score matching yielded 335 pairs. After matching, mortality did not differ significantly between the groups: in\u2010hospital mortality 14.0% versus 17.3% (adjusted odds ratio [aOR], 1.29; 95% confidence interval [CI], 0.84\u20131.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.240), 24\u2010h mortality 4.5% versus 5.1% (aOR, 1.13; 95% CI, 0.57\u20132.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.724), and 28\u2010day mortality 9.3% versus 11.9% (aOR, 1.36; 95% CI, 0.81\u20132.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.243).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective cohort study, a 1\u2010g TXA bolus alone was associated with mortality outcomes comparable to those of the conventional bolus\u2010plus\u2010infusion regimen among patients treated within 3\u00a0hours of injury. Prospective studies are warranted to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70587","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:35:10Z","timestamp":1791120910000},"source":"Crossref","is-referenced-by-count":0,"title":["Bolus\u2010Only Versus Bolus\u2010Plus\u2010Infusion Tranexamic Acid for Trauma: A Propensity Score\u2010Matched Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5966-9030","authenticated-orcid":false,"given":"Soon Ki","family":"Min","sequence":"first","affiliation":[{"name":"Department of Trauma Surgery Gachon University Gil Medical Center  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-4330","authenticated-orcid":false,"given":"Kang Kook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-2343","authenticated-orcid":false,"given":"Byungchul","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-5933","authenticated-orcid":false,"given":"Gil Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-8993","authenticated-orcid":false,"given":"Min A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7325-8262","authenticated-orcid":false,"given":"Seunghwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-4312","authenticated-orcid":false,"given":"Sebeom","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Traumatology Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-0385","authenticated-orcid":false,"given":"Myungjin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery Gachon University Gil Medical Center  Incheon Republic of 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