{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:52:28Z","timestamp":1791125548115,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunosuppressed patients are more at risk of perioperative infections. In case of ventral hernia repair, the use of a long\u2010term absorbable mesh could potentially decrease the infectious risk in these patients. This study aimed to assess the short\u2010 and mid\u2010term outcomes of ventral hernia repair with long\u2010term absorbable mesh in immunosuppressed and non\u2010immunosuppressed patients compared with permanent mesh in non\u2010immunosuppressed patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted in two tertiary centers in France. Consecutive patients who underwent ventral hernia repair with a long\u2010term absorbable (poly\u20104\u2010hydroxybutyrate, P4HB) mesh between 2017 and 2024 were included. Immunosuppression was defined as a decreased immunity level caused by a disease or medication. Outcomes of these patients were compared to non\u2010immunosuppressed patients who underwent ventral hernia repair with P4HB mesh and with synthetic mesh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 465 patients were included: 27 in the immunosuppressed group with P4HB mesh, 232 non\u2010immunosuppressed patients with P4HB mesh, and 206 non\u2010immunosuppressed patients with synthetic mesh. Among patients with P4HB mesh, no differences in postoperative outcomes were found between the immunosuppressed and non\u2010immunosuppressed groups (mean follow\u2010up: 15\u00a0months, 95% CI 12\u201317). When comparing immunosuppressed patients with P4HB to non\u2010immunosuppressed patients with synthetic mesh, the morbidity rate was higher in immunosuppressed patients (12\/27\u00a0=\u00a044% vs. 38\/206\u00a0=\u00a018%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), while surgical site infection, mesh infection, or recurrence rates were similar (mean follow\u2010up: 19\u00a0months, 95% CI 16\u201323). Immunosuppression was not found as a predictor of surgical site infection (OR 5.0, 95% CI 0.7\u201310.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.091).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immunosuppressed patients with P4HB mesh had similar short\u2010 and mid\u2010term infectious complications to non\u2010immunosuppressed patients. Long\u2010term recurrence rates remain to be evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/wjs.70609","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:03:57Z","timestamp":1791122637000},"source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Long\u2010Term Absorbable Mesh Use for Ventral Hernia Repair in Immunosuppressed Patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-3494","authenticated-orcid":false,"given":"Ga\u00ebtan\u2010Romain","family":"Joliat","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery Lausanne University Hospital CHUV, University of Lausanne (UNIL)  Lausanne Switzerland"},{"name":"Department of General Surgery and Surgical Oncology Centre Hospitalier Universitaire Lyon Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-1079","authenticated-orcid":false,"given":"Benoit","family":"Romain","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hautepierre Hospital  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-3491","authenticated-orcid":false,"given":"Guillaume","family":"Passot","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology Centre Hospitalier Universitaire Lyon Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.28019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000099"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.11.030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010023\u201002879\u20109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16212"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2023.01.020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.10.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010025\u201003395\u20108"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010020\u201005808\u20104"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010024\u201002996\u2010z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/646436"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010018\u20101813\u20101"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.12.024"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14393"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.05.023"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029\u2010025\u201003273\u20103"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010025\u201012249\u20104"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010023\u201010537\u20105"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wjs.70609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wjs.70609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:03:57Z","timestamp":1791122637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wjs.70609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":19,"alternative-id":["10.1002\/wjs.70609"],"URL":"https:\/\/doi.org\/10.1002\/wjs.70609","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"article-number":"wjs.70609"}}