{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:51:37Z","timestamp":1792475497914,"version":"4.5.0"},"reference-count":169,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Membr Transp Signal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>L\u2010type calcium channels (Cav1) represent one of the three major classes (Cav1\u20133) of voltage\u2010gated calcium channels. They were identified as the target of clinically used calcium channel blockers (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s; so\u2010called calcium antagonists) and were the first class accessible to biochemical characterization. Four of the 10 known \u03b11 subunits (Cav1.1\u2013Cav1.4) form the pore of L\u2010type calcium channels (<jats:styled-content style=\"fixed-case\">LTCC<\/jats:styled-content>s) and contain the high\u2010affinity drug\u2010binding sites for dihydropyridines and other chemical classes of organic <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s. In essentially all electrically excitable cells one or more of these <jats:styled-content style=\"fixed-case\">LTCC<\/jats:styled-content> isoforms is expressed, and therefore it is not surprising that many body functions including muscle, brain, endocrine, and sensory function depend on proper <jats:styled-content style=\"fixed-case\">LTCC<\/jats:styled-content> activity. Gene knockouts and inherited human diseases have allowed detailed insight into the physiological and pathophysiological role of these channels. Genome\u2010wide association studies and analysis of human genomes are currently providing even more hints that even small changes of channel expression or activity may be associated with disease, such as psychiatric disease or cardiac arrhythmias. Therefore, it is important to understand the structure\u2013function relationship of <jats:styled-content style=\"fixed-case\">LTCC<\/jats:styled-content> isoforms, their differential contribution to physiological function, as well as their fine\u2010tuning by modulatory cellular processes. <jats:italic>WIREs Membr Transp Signal<\/jats:italic> 2014,3:15\u201338. doi: 10.1002\/wmts.102<\/jats:p><jats:p>Conflict of interest: The authors have declared no conflicts of interest for this article.<\/jats:p><jats:p>For further resources related to this article, please visit the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/wires.wiley.com\/remdoi.cgi?doi=10.1002\/wmts.102\">WIREs website<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/wmts.102","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T16:51:41Z","timestamp":1390323101000},"page":"15-38","source":"Crossref","is-referenced-by-count":220,"title":["L\u2010type Ca<sup>2+<\/sup> channels in heart and brain"],"prefix":"10.1002","volume":"3","author":[{"given":"J\u00f6rg","family":"Striessnig","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pinggera","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronel","family":"Tuluc","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Institute of Pharmacy and Center of Molecular Biosciences University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003947"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3311"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01171-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005940107"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2694"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.047068"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200910308"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000253095.44186.72"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-011-9269-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001152"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000312"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199828"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914287107"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505155"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.07.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503465103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.196972"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.11.032"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224717"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.043497"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.175257"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.032"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5523-03.2004"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611384200"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4367-09.2010"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5191-06.2007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03446.2003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.10.029"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100929200"},{"key":"e_1_2_11_33_1","first-page":"551","article-title":"Functional interactions between voltage\u2010gated Ca2+ channels and Rab3\u2010interacting molecules (RIMs): new insights into stimulus\u2010secretion coupling","volume":"2012","author":"Gandini MA","year":"1818","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4554-04.2005"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191086"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191027"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2727"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.09.012"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.2.4.5847"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2008.09.027"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101469200"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.269951"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0935295100"},{"key":"e_1_2_11_44_1","first-page":"1243","article-title":"Ca2+\u2010dependent modulation of voltage\u2010gated Ca2+ channels","volume":"2012","author":"Christel C","year":"1820","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3236-06.2006"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1751"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802254200"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111799"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0635-5"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016320"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1674-8301(10)60027-9"},{"key":"e_1_2_11_52_1","first-page":"1629","article-title":"Regulation of Cav2 calcium channels by G protein coupled receptors","volume":"2013","author":"Zamponi GW","year":"1828","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.4809"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20208"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/298576a0"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409885102"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.10.017"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.191387"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319421110"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215219109"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.216127"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi101018c"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2302-12.2012"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607294103"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44747"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2007"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000202692.23001.e2"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804981200"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.366484"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.236729"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809132200"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.4284"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2038"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2327"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00076-X"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.10.019"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0481-06.2006"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2005.05.005"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200910203"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121434109"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10370"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.03.015"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00057.2009"},{"key":"e_1_2_11_84_1","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1523\/JNEUROSCI.23-14-06041.2003","article-title":"Cav1.4\u03b11 subunits can form slowly inactivating dihydropyridine\u2010sensitive L\u2010type calcium channels lacking calcium\u2010dependent inactivation","volume":"23","author":"Koschak A","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7377com"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093195"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.214247"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.06.008"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2712"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.20865"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202476200"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.227819"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13877"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.045583"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)70027-7"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.12.006"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00013-1"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.03.022"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg032"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs260"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601868"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.239954"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000225862.14314.49"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.5.3.15266"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.5.3.15264"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000018003.14304.E2"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113310"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006467200"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58227"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.357921"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.210237"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252312"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.175307"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.06.024"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.11.012"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2067"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502506102"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710501105"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34355"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1457"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224279"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.049981"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.022"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709990368"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.4.949"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3213-08.2008"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04734.x"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805048"},{"key":"e_1_2_11_129_1","first-page":"97","article-title":"Exploring the dominant role of Cav1 channels in signalling to the nucleus","volume":"33","author":"Ma H","year":"2013","journal-title":"Biosci Rep"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3327-04.2005"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi062217x"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4673-09.2010"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi336"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00146.2007"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1531-05.2005"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.773208"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.10.009"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20728"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.279006"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.886208"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.06.012"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4164-08.2010"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.71"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.01.059"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3307"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62129-1"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.06.001"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2255-10.2010"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2315-11.2011"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.19324"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.09.008"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.004"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05865"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.04.007"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199503000-00009"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)00917-1"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.12.003"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4742-09.2009"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4341-06.2007"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2519-09.2009"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.033"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21937"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000303818.38960.44"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr362"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23191"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0765-12.2012"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5098-10.2011"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds217"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/314094a0"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097060"}],"container-title":["Wiley Interdisciplinary Reviews: Membrane Transport and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwmts.102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wmts.102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wmts.102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wmts.102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:58:18Z","timestamp":1697443098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wmts.102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,21]]},"references-count":169,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/wmts.102"],"URL":"https:\/\/doi.org\/10.1002\/wmts.102","archive":["Portico"],"relation":{},"ISSN":["2190-460X","2190-4618"],"issn-type":[{"value":"2190-460X","type":"print"},{"value":"2190-4618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,21]]}}}