{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:08Z","timestamp":1787169608017,"version":"build-2736575974"},"reference-count":124,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571803"],"award-info":[{"award-number":["81571803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870997"],"award-info":[{"award-number":["31870997"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010871","name":"Recruitment Program of Global Experts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs Nanomed Nanobiotechnol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the past few decades, nanotechnology has proven to be one of the most powerful engineering strategies. The nanotechnologies for osteochondral tissue engineering aim to restore the anatomical structures and physiological functions of cartilage, subchondral bone, and osteochondral interface. As subchondral bone and articular cartilage have different anatomical structures and the physiological functions, complete healing of osteochondral defects remains a great challenge. Considering the limitation of articular cartilage to self\u2010healing and the complexity of osteochondral tissue, osteochondral defects are in urgently need for new therapeutic strategies. This review article will concentrate on the most recent advancements of nanotechnologies, which facilitates chondrogenic and osteogenic differentiation for osteochondral regeneration. Moreover, this review will also discuss the current strategies and physiological challenges for the regeneration of osteochondral tissue. Specifically, we will summarize the latest developments of nanobased scaffolds for simultaneously regenerating subchondral bone and articular cartilage tissues. Additionally, perspectives of nanotechnology in osteochondral tissue engineering will be highlighted. This review article provides a comprehensive summary of the latest trends in cartilage and subchondral bone regeneration, paving the way for nanotechnologies in osteochondral tissue engineering.<\/jats:p>\n                  <jats:p>This article is categorized under:<\/jats:p>\n                  <jats:p>Implantable Materials and Surgical Technologies &gt; Nanomaterials and Implants<\/jats:p>\n                  <jats:p>Nanotechnology Approaches to Biology &gt; Nanoscale Systems in Biology<\/jats:p>\n                  <jats:p>Implantable Materials and Surgical Technologies &gt; Nanotechnology in Tissue Repair and Replacement<\/jats:p>","DOI":"10.1002\/wnan.1576","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T10:06:03Z","timestamp":1563789963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Advances of nanotechnology in osteochondral regeneration"],"prefix":"10.1002","volume":"11","author":[{"given":"Cuijun","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai East Hospital, The Institute for Biomedical Engineering &amp; Nano Science Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai East Hospital, The Institute for Biomedical Engineering &amp; Nano Science Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai East Hospital, The Institute for Biomedical Engineering &amp; Nano Science Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-1292","authenticated-orcid":false,"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai East Hospital, The Institute for Biomedical Engineering &amp; Nano Science Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2467-2"},{"key":"e_1_2_11_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.166"},{"key":"e_1_2_11_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01224.x"},{"key":"e_1_2_11_2_4_1","first-page":"278","article-title":"Viscosupplementation for treatment of osteoarthritis: From initial discovery to current status and results","volume":"12","author":"Balazs E. A.","year":"2004","journal-title":"Surgical Technology International"},{"key":"e_1_2_11_2_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00895"},{"key":"e_1_2_11_2_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0NR00493F"},{"key":"e_1_2_11_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311401"},{"key":"e_1_2_11_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1201-1141"},{"key":"e_1_2_11_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proghi.2010.11.001"},{"issue":"4","key":"e_1_2_11_2_10_1","first-page":"B4600","article-title":"Advances in autologous chondrocyte implantation and related techniques for cartilage repair","volume":"60","author":"Casper Bindzus F.","year":"2013","journal-title":"Danish Medical Journal"},{"key":"e_1_2_11_2_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR03425F"},{"key":"e_1_2_11_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.10.024"},{"key":"e_1_2_11_2_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22514"},{"key":"e_1_2_11_2_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22514"},{"key":"e_1_2_11_2_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/la036154k"},{"key":"e_1_2_11_2_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201806068"},{"key":"e_1_2_11_2_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151434"},{"key":"e_1_2_11_2_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510392711"},{"issue":"1","key":"e_1_2_11_2_19_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jor.20958","article-title":"Orderly osteochondral regeneration in a sheep model using a novel nano\u2010composite multilayered biomaterial","volume":"28","author":"Elizaveta K.","year":"2010","journal-title":"Journal of Orthopaedic Research"},{"issue":"9","key":"e_1_2_11_2_20_1","first-page":"27","article-title":"Nanotechnology and medicine","volume":"65","author":"Emerich D. F.","year":"2004","journal-title":"Radiology"},{"key":"e_1_2_11_2_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/22\/3\/035102"},{"key":"e_1_2_11_2_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-011-0253-2"},{"key":"e_1_2_11_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.010"},{"key":"e_1_2_11_2_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/10763270260424187"},{"key":"e_1_2_11_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2018.08.006"},{"key":"e_1_2_11_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2005.07.029"},{"key":"e_1_2_11_2_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12448454"},{"key":"e_1_2_11_2_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2014.951244"},{"key":"e_1_2_11_2_29_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.02010"},{"issue":"6","key":"e_1_2_11_2_30_1","first-page":"751","article-title":"Synergistic enhancement of bone formation and healing by stem cell\u2010expressed VEGF and bone morphogenetic protein\u20104","volume":"355","author":"Hairong P.","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"e_1_2_11_2_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15085525"},{"key":"e_1_2_11_2_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0053-z"},{"key":"e_1_2_11_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.07.006"},{"issue":"1","key":"e_1_2_11_2_34_1","first-page":"3619","article-title":"Effects of titanium nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells","volume":"2013","author":"Hou Y.","year":"2013","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_11_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.12.034"},{"key":"e_1_2_11_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.013"},{"key":"e_1_2_11_2_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222454"},{"key":"e_1_2_11_2_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0814"},{"key":"e_1_2_11_2_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0556-4"},{"key":"e_1_2_11_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.12.023"},{"key":"e_1_2_11_2_41_1","doi-asserted-by":"crossref","unstructured":"Jensen T. Baas J. Dolathshahi\u2010Pirouz A. Jacobsen T. Singh G. Nygaard J. V. \u2026Soballe K.(2011). Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation.Journal of Biomedical Materials Research Part A 99A(1) 94\u2013101.","DOI":"10.1002\/jbm.a.33166"},{"key":"e_1_2_11_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.03.005"},{"key":"e_1_2_11_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.028"},{"key":"e_1_2_11_2_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2013.0543"},{"key":"e_1_2_11_2_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0388"},{"key":"e_1_2_11_2_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1978"},{"key":"e_1_2_11_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.12.077"},{"key":"e_1_2_11_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.03.008"},{"key":"e_1_2_11_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2004.07.004"},{"key":"e_1_2_11_2_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509351649"},{"key":"e_1_2_11_2_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32441"},{"key":"e_1_2_11_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.054"},{"key":"e_1_2_11_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(98)00274-7"},{"key":"e_1_2_11_2_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10611860701289818"},{"key":"e_1_2_11_2_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200382"},{"key":"e_1_2_11_2_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199310000-00009"},{"key":"e_1_2_11_2_57_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.118"},{"key":"e_1_2_11_2_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbv015"},{"key":"e_1_2_11_2_59_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/9\/6\/065004"},{"key":"e_1_2_11_2_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-4118-1"},{"key":"e_1_2_11_2_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b00862"},{"key":"e_1_2_11_2_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-52"},{"key":"e_1_2_11_2_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1054-z"},{"key":"e_1_2_11_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.02.018"},{"key":"e_1_2_11_2_65_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.5477"},{"key":"e_1_2_11_2_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.11.1469"},{"key":"e_1_2_11_2_67_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v023a17"},{"key":"e_1_2_11_2_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-5-9"},{"key":"e_1_2_11_2_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1634"},{"key":"e_1_2_11_2_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.10.024"},{"key":"e_1_2_11_2_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076612"},{"key":"e_1_2_11_2_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl070678d"},{"key":"e_1_2_11_2_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.04.022"},{"key":"e_1_2_11_2_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01571.x"},{"key":"e_1_2_11_2_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290054029"},{"key":"e_1_2_11_2_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949901101900122"},{"key":"e_1_2_11_2_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10585"},{"key":"e_1_2_11_2_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110001-00004"},{"key":"e_1_2_11_2_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31697"},{"key":"e_1_2_11_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.011"},{"key":"e_1_2_11_2_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.056"},{"key":"e_1_2_11_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03610-2"},{"key":"e_1_2_11_2_83_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S16354"},{"key":"e_1_2_11_2_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/1876402910901010050"},{"key":"e_1_2_11_2_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.11.036"},{"key":"e_1_2_11_2_86_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504271965"},{"key":"e_1_2_11_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2017.02.006"},{"key":"e_1_2_11_2_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4397-1"},{"key":"e_1_2_11_2_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2011.12.009"},{"key":"e_1_2_11_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.04.003"},{"key":"e_1_2_11_2_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9704-3"},{"key":"e_1_2_11_2_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200110001-00033"},{"key":"e_1_2_11_2_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092508"},{"key":"e_1_2_11_2_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010087"},{"key":"e_1_2_11_2_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-014-1698-8"},{"key":"e_1_2_11_2_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11687"},{"key":"e_1_2_11_2_97_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/22\/1\/015104"},{"key":"e_1_2_11_2_98_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200311000-00006"},{"key":"e_1_2_11_2_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-006-0182-y"},{"key":"e_1_2_11_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(98)80010-1"},{"key":"e_1_2_11_2_101_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S30320"},{"issue":"23","key":"e_1_2_11_2_102_1","first-page":"S160","article-title":"Biphasic and dosage\u2010dependent regulation of osteoclastogenesis by beta\u2010catenin","volume":"48","author":"Wan Y.","year":"2011","journal-title":"Molecular and Cellular Biology"},{"key":"e_1_2_11_2_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.018"},{"key":"e_1_2_11_2_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.05.009"},{"key":"e_1_2_11_2_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34002"},{"key":"e_1_2_11_2_106_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0184"},{"key":"e_1_2_11_2_107_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.183"},{"key":"e_1_2_11_2_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.08.042"},{"key":"e_1_2_11_2_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.024"},{"key":"e_1_2_11_2_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00944j"},{"key":"e_1_2_11_2_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32691"},{"key":"e_1_2_11_2_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.07.060"},{"key":"e_1_2_11_2_113_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2008.0371"},{"key":"e_1_2_11_2_114_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB02308H"},{"key":"e_1_2_11_2_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.01.050"},{"key":"e_1_2_11_2_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.329"},{"key":"e_1_2_11_2_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2617"},{"key":"e_1_2_11_2_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.01.013"},{"key":"e_1_2_11_2_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201703795"},{"key":"e_1_2_11_2_120_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4276"},{"key":"e_1_2_11_2_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.01.006"},{"key":"e_1_2_11_2_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.04.030"},{"key":"e_1_2_11_2_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-011-9367-4"},{"key":"e_1_2_11_2_124_1","doi-asserted-by":"publisher","DOI":"10.1088\/1468-6996\/14\/4\/045005"}],"container-title":["WIREs Nanomedicine and Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.1576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wnan.1576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.1576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T03:26:05Z","timestamp":1721532365000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wnan.1576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":124,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/wnan.1576"],"URL":"https:\/\/doi.org\/10.1002\/wnan.1576","archive":["Portico"],"relation":{},"ISSN":["1939-5116","1939-0041"],"issn-type":[{"value":"1939-5116","type":"print"},{"value":"1939-0041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2019-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1576"}}