{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:10:48Z","timestamp":1787163048750,"version":"build-2736575974"},"reference-count":192,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C55939\/A22570"],"award-info":[{"award-number":["C55939\/A22570"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs Nanomed Nanobiotechnol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspects of tumor biology together with the physicochemical features of the nanocarrier, that need to be considered in order to develop effective nanotherapeutics for colorectal cancer patients with liver metastases. It becomes clear that incorporating an interdisciplinary approach when developing nanomedicines should assure appropriate disease\u2010driven design and that this will form a critical step in improving their clinical translation.<\/jats:p>\n                  <jats:p>\n                    This article is characterized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Oncologic Disease<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wnan.1588","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:19:24Z","timestamp":1569889164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Critical considerations for targeting colorectal liver metastases with nanotechnology"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-1885","authenticated-orcid":false,"given":"Usman","family":"Arshad","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne B.","family":"Ashford","sequence":"additional","affiliation":[{"name":"AstraZeneca, Advanced Drug Delivery, Pharmaceutical Sciences, R&amp;D  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E.","family":"Treacher","sequence":"additional","affiliation":[{"name":"AstraZeneca, Pharmaceutical Technology and Development  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill J.","family":"Liptrott","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, Materials Innovation Factory University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve P.","family":"Rannard","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Materials Innovation Factory University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Goldring","sequence":"additional","affiliation":[{"name":"MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, Materials Innovation Factory University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.06.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2017.1270"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000255690.03436.ae"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp800051m"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760607"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad2355"},{"key":"e_1_2_12_9_1","unstructured":"AstraZeneca. (2019).Pipeline\u2014AstraZeneca. Retrieved fromwww.astrazeneca.com\/our-science\/pipeline"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.06.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12854"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.576"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0515"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.4108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.11.009"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_18_1","volume-title":"TNM classification of malignant tumours","author":"Brierley J.","year":"2017"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0292-9"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0460"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0083-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2018.01.016"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6ra05825f"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06995"},{"key":"e_1_2_12_25_1","unstructured":"Cancer Research UK. (2018).Bowel cancer statistics. Retrieved fromwww.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1996.4977"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.72"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.09.014"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03109"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.09.047"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300558p"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0194"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-10-36"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.129"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21292"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.016"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0295"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11020032"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2705"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.11.003"},{"issue":"6","key":"e_1_2_12_41_1","first-page":"737","article-title":"Complications related to hyperthermia during hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) treatment. Do they exist?","volume":"16","author":"Di Miceli D.","year":"2012","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.12.022"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060302"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.02.022"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2018.10.003"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4228"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3925-x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7755-1_4"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472630317697251"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4197"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.04.003"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342050-00002"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs306"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b05119"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28358"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2010"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.007"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30953-1"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781782622536"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.001"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.04.011"},{"key":"e_1_2_12_62_1","unstructured":"Halozyme. (2019).Halozyme therapeutics\u2014PEGPH20 a therapeutic candidate for the treatment of HA\u2010HIGH cancer. Retrieved fromwww.halozyme.com\/technology\/product-candidate\/pegph20"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.04.025"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm700535p"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21778"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2577-7"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2264-z"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33808"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24166"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-06-0003"},{"key":"e_1_2_12_72_1","unstructured":"Ipsen Pharma. (2019).ONIVYDE\u00ae(Irinotecan liposome injection):Health Care Professional Info. Retrieved fromwww.onivyde.com"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050721"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.139"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4102"},{"key":"e_1_2_12_76_1","unstructured":"Jazz Pharmaceuticals. (2019).Acute myeloid leukemia(AML)treatment.VYXEOS\u00ae(daunorubicin and cytarabine). Retrieved fromhttps:\/\/vyxeos.com\/"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00404"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-101914-6.00008-9"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b02028"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0029"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.12.002"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2017.93.4.173"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2019.05.011"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24384"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-019-09954-5"},{"key":"e_1_2_12_86_1","unstructured":"Kayaku N. (2019).Status of new drug development. Retrieved fromhttps:\/\/www.nipponkayaku.co.jp\/english\/ir\/business\/files\/pharmaceuticals.pdf"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.018"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902672"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7193"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1605"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar2000138"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2013.07.001"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0181-9"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.65"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00241"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21051"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00006"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.100"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9591-y"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29857"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.2217\/hep-2016-0005"},{"issue":"22","key":"e_1_2_12_102_1","first-page":"6371","article-title":"Interstitial hypertension in human tumors. 4. Interstitial hypertension in human breast and colorectal tumors","volume":"52","author":"Less J. R.","year":"1992","journal-title":"Cancer Research"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.01.026"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b01788"},{"key":"e_1_2_12_105_1","unstructured":"LipoMedix. (2019).LipoMedix\u00ae\u2014Product\u2010Promitil. Retrieved fromhttp:\/\/lipomedix.com\/Products\/%C2%AEProduct-Promitil"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2432060341"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.07.030"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010029"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8tb01932k"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30332-2"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06245"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31343"},{"issue":"12","key":"e_1_2_12_114_1","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura Y.","year":"1986","journal-title":"Cancer Research"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1636"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S146927"},{"key":"e_1_2_12_117_1","unstructured":"MiNA Therapeutics. (2019).PIPELINE\u2014MiNA therapeutics RNA activation. Retrieved fromwww.minatx.com\/pipeline\/#section_two"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0073-3"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2018-000217"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23381"},{"key":"e_1_2_12_121_1","unstructured":"Nektar. (2019).Nektar: R&D Pipeline\u2014Onzeald\u2122(etirinotecan pegol). Retrieved fromwww.nektar.com\/pipeline\/rd-pipeline\/onzeald"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071700"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.2147\/Ijn.S129300"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7876-8_2"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.2147\/Ijn.S26592"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6280347"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20886"},{"issue":"3","key":"e_1_2_12_128_1","first-page":"926","article-title":"Morphological aspects of angiogenesis in experimental liver metastases","volume":"143","author":"Paku S.","year":"1993","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/686879"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.01.013"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.05.016"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/10611860701794353"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i14.3719"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8072-7"},{"issue":"1","key":"e_1_2_12_135_1","first-page":"153","article-title":"Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: A study in CC\u2010531 liver tumor\u2010bearing WAG RIJ rats","volume":"31","author":"Pohlen U.","year":"2011","journal-title":"Anticancer Research"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.058"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4561"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.229"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.26"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1042\/Bj20031253"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233512"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712185"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.107"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03705-y"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2017.1279361"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)63247-3"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-4-10"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.07.014"},{"key":"e_1_2_12_149_1","unstructured":"Samyang Biopharm. (2019).Genexol PM. Retrieved fromhttps:\/\/samyangbiopharm.com\/eng\/ProductIntroduce\/injection01"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4456"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.137"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-017-0004-3"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007336"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2008.12.004"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140078"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601727"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.02.005"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006225"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.03.007"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139752"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00544"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-10-1467"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1576"},{"key":"e_1_2_12_165_1","unstructured":"Teva UK. (2019).Myocet\u00ae(Doxorubicin hydrochloride).Teva UK Limited. Retrieved fromwww.tevauk.com\/hcp\/myocet"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.022"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0175-0"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4718"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1546"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.334"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-012-9469-1"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-12-3931"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005087"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.982"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.11.004"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-11-1965"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2084338"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4tb01611d"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<285::Aid-Cncr12>3.0.Co;2-#"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-019-0237-6"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-947-7_2"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5nr04831a"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.021"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.2741\/4190"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.014"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.038"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.048"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4nr07450e"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10525"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.020"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04947"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11888-015-0269-2"}],"container-title":["WIREs Nanomedicine and Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwnan.1588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.1588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wnan.1588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.1588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:13:26Z","timestamp":1693188806000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wnan.1588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":192,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/wnan.1588"],"URL":"https:\/\/doi.org\/10.1002\/wnan.1588","archive":["Portico"],"relation":{},"ISSN":["1939-5116","1939-0041"],"issn-type":[{"value":"1939-5116","type":"print"},{"value":"1939-0041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1588"}}