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Regenerative nanomedicine uses nanoparticles containing gene transcription factors and other modulating molecules that allow reprogramming of cells <jats:italic>in vivo<\/jats:italic> as well as nanomaterials to induce selective differentiation of neural progenitor cells and to create neural\u2010mechanical interfaces. In this article, we consider some applications of nanotechnology that may be useful for the treatment of degenerative retinal diseases, for example, use of nanoparticles for drug and gene therapy, use of nanomaterials for neural interfaces and extracellular matrix construction for cell\u2010based therapy and neural prosthetics, and the use of bionanotechnology to re\u2010engineer proteins and cell behavior for regenerative medicine. <jats:italic>WIREs Nanomed Nanobiotechnol<\/jats:italic> 2012, 4:113\u2013137. doi: 10.1002\/wnan.167<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Implantable Materials and Surgical Technologies &gt; Nanomaterials and Implants<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Neurological Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Implantable Materials and Surgical Technologies &gt; Nanotechnology in Tissue Repair and Replacement<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Implantable Materials and Surgical Technologies &gt; Nanoscale Tools and Techniques in Surgery<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wnan.167","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T19:41:29Z","timestamp":1323891689000},"page":"113-137","source":"Crossref","is-referenced-by-count":22,"title":["Regenerative nanomedicine and the treatment of degenerative retinal diseases"],"prefix":"10.1002","volume":"4","author":[{"given":"Marco A.","family":"Zarbin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Montemagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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