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Various testing kits and assays, including nucleic acid detection methods, antigen tests, serological tests, and enzyme\u2010linked immunosorbent assay (ELISA), have been implemented or are being explored to detect the virus and\/or characterize cellular and antibody responses to the infection. However, these approaches have inherent drawbacks such as nonspecificity, high cost, are characterized by long turnaround times for test results, and can be labor\u2010intensive. Also, the circulating SARS\u2010COV\u20102 variant of concerns, reduced antibody sensitivity and\/or neutralization, and possible antibody\u2010dependent enhancement (ADE) have warranted the search for alternative potent therapeutics. Aptamers, which are single\u2010stranded oligonucleotides, generated artificially by SELEX (Evolution of Ligands by Exponential Enrichment) may offer the capacity to generate high\u2010affinity neutralizers and\/or bioprobes for monitoring relevant SARS\u2010COV\u20102 and COVID\u201019 biomarkers. This article reviews and discusses the prospects of implementing aptamers for rapid point\u2010of\u2010care detection and treatment of SARS\u2010COV\u20102. We highlight other SARS\u2010COV\u20102 targets (N protein, spike protein stem\u2010helix), SELEX augmented with competition assays and\n                    <jats:italic>in silico<\/jats:italic>\n                    technologies for rapid discovery and isolation of theranostic aptamers against COVID\u201019 and future pandemics. It further provides an overview on site\u2010specific bioconjugation approaches, customizable molecular scaffolding strategies, and nanotechnology platforms to engineer these aptamers into ultrapotent blockers, multivalent therapeutics, and vaccines to boost both humoral and cellular immunity against the virus.\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Diagnostic Tools &gt; Biosensing<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Infectious Disease<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Respiratory Disease<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wnan.1785","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T05:59:41Z","timestamp":1646287181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aptamers as promising nanotheranostic tools in the\n                    <scp>COVID<\/scp>\n                    \u201019 pandemic era"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-051X","authenticated-orcid":false,"given":"Christian K. 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