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Emerging viruses are a constant threat due to the substantial variation in viral structures, limiting the potential for expanded broad\u2010spectrum antiviral agent development, and the complexity of targeting multiple and diverse viral species with unique characteristics involving their virulence. Multiple, more infectious variants of SARS\u2010CoV2 (e.g., Delta, Omicron) have already appeared, necessitating research into versatile, robust control strategies in response to the looming threat of future viruses. Nanotechnology and nanomaterials have played a vital role in addressing current viral threats, from mRNA\u2010based vaccines to nanoparticle\u2010based drugs and nanotechnology enhanced disinfection methods. Rapid progress in the field has prompted a review of the current literature primarily focused on nanotechnology\u2010based virucides and antivirals. In this review, a brief description of antiviral drugs is provided first as background with most of the discussion focused on key design considerations for high\u2010efficacy antiviral nanomaterials (e.g., nanopharmaceuticals) as determined from published studies as well as related modes of biological activity. Insights into potential future research directions are also provided with a section devoted specifically to the SARS\u2010CoV2 virus.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Toxicology and Regulatory Issues in Nanomediciney &gt; Toxicology of Nanomaterials<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Infectious Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Respiratory Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wnan.1823","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T02:28:37Z","timestamp":1655173717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiviral nanopharmaceuticals: Engineered surface interactions and virus\u2010selective activity"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2615-6866","authenticated-orcid":false,"given":"Elayaraja","family":"Kolanthai","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, Advanced Materials Processing and Analysis Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-4229","authenticated-orcid":false,"given":"Craig J.","family":"Neal","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Advanced Materials Processing and Analysis Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5216-8970","authenticated-orcid":false,"given":"Udit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Advanced Materials Processing and Analysis Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-9031","authenticated-orcid":false,"given":"Yifei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Advanced Materials Processing and Analysis Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-3344","authenticated-orcid":false,"given":"Sudipta","family":"Seal","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Advanced Materials Processing and Analysis Center University of Central Florida  Orlando Florida USA"},{"name":"College of Medicine, Nanoscience Technology Center, Biionix Cluster University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.1c03033"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111724"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00238"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00316-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2021.666548"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b04644"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oceram.2020.100006"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200902384"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc900215b"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b12950"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja710321g"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200700863"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06793"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00685-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520967933"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00875c"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn503573s"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.10.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00763.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"crossref","unstructured":"Crane M. 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