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In the field of Nanomedicine, advances in nanotechnology have been applied with great success to design and develop novel nanoparticle\u2010based formulations for the treatment of various types of cancer. The approval of the first nanomedicine, Doxil\u00ae (liposomal doxorubicin) in 1995, paved the path for further development for various types of novel delivery platforms. Several different types of nanoparticles, especially organic (soft) nanoparticles (liposomes, polymeric micelles, and albumin\u2010bound nanoparticles), have been developed and approved for several anticancer drugs. Nanoparticulate drug delivery platform\u00a0have facilitated to overcome of these challenges and offered key advantages of improved bioavailability, higher intra\u2010tumoral concentration of the drug, reduced toxicity, and improved efficacy. This review introduces various commonly used nanoparticulate systems in biomedical research and their pharmacokinetic (PK) attributes, then focuses on the various physicochemical and physiological factors affecting the <jats:italic>in vivo<\/jats:italic> disposition of chemotherapeutic agents encapsulated in nanoparticles in recent years. Further, it provides a review of the current landscape of soft nanoparticulate formulations for the two most widely investigated anticancer drugs, paclitaxel, and doxorubicin, that are either approved or under investigation. Formulation details, PK profiles, and therapeutic outcomes of these novel strategies have been discussed individually and in comparison, to traditional formulations.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Nanotechnology Approaches to Biology &gt; Cells at the Nanoscale<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Diagnostic Tools &gt; In Vivo Nanodiagnostics and Imaging<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Oncologic Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wnan.1846","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T09:24:32Z","timestamp":1660814672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pharmacokinetic behaviors of soft nanoparticulate formulations of chemotherapeutics"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-0088","authenticated-orcid":false,"given":"Mahua","family":"Sarkar","sequence":"first","affiliation":[{"name":"College of Pharmacy and Health Sciences Texas Southern University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0429-9412","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Health Sciences Texas Southern University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-3725","authenticated-orcid":false,"given":"Oscar","family":"Ekpenyong","sequence":"additional","affiliation":[{"name":"Merck &amp; Co  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-8066","authenticated-orcid":false,"given":"Dong","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Health Sciences Texas Southern University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-5619","authenticated-orcid":false,"given":"Huan","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Health Sciences Texas Southern University  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnano.2021.681305"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics6010137"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1660970"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.03.018"},{"key":"e_1_2_11_6_1","first-page":"763","volume-title":"Meyler's side effects of drugs","author":"Aronson J. 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