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Reducing the burden of NTDs requires sustained collaborative drug discovery efforts to achieve the goals of the new NTDs roadmap launched by the World Health Organization. Oral drugs are the most convenient choice and usually the safest and least expensive. However, the oral use of some drugs for NTDs treatment has many drawbacks, including toxicity, adverse reactions, drug resistance, drug low solubility, and bioavailability. Since there is an imperative need for novel and more effective drugs to treat the various NTDs, in recent years, several compound\u2010loaded nanoparticles have been prepared with the objective of evaluating their application as an oral drug delivery system for the treatment of NTDs. This review focuses on the various types of nanoparticle drug delivery systems that have been recently used against the major NTDs caused by parasites such as leishmaniasis, Chagas disease, and schistosomiasis.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Infectious Disease<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wnan.1852","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T20:30:15Z","timestamp":1664137815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Recent approaches in nanocarrier\u2010based therapies for neglected tropical diseases"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-425X","authenticated-orcid":false,"given":"Ana C.","family":"Mengarda","sequence":"first","affiliation":[{"name":"Research Center for Neglected Diseases Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-7608","authenticated-orcid":false,"given":"Bruno","family":"Iles","sequence":"additional","affiliation":[{"name":"Department of Genetics and Morphology, Institute of Biological Sciences University of Bras\u00edlia  Bras\u00edlia Distrito Federal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-7263","authenticated-orcid":false,"given":"Jo\u00e3o Paulo F.","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Genetics and Morphology, Institute of Biological Sciences University of Bras\u00edlia  Bras\u00edlia Distrito Federal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":false,"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.02.019"},{"key":"e_1_2_11_2_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009423"},{"key":"e_1_2_11_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.21"},{"key":"e_1_2_11_2_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa167"},{"key":"e_1_2_11_2_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01937-19"},{"key":"e_1_2_11_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"e_1_2_11_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_2_11_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.101843"},{"key":"e_1_2_11_2_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0308"},{"key":"e_1_2_11_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.04.005"},{"key":"e_1_2_11_2_11_1","unstructured":"DNDi. 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