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However, future deep space travel requires addressing health concerns for crews under continuous, longer\u2010term exposure to adverse environmental conditions. Among these challenges, radiation\u2010induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro\u2010gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio\u2010absorption cross\u2010section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon\u2010based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation\u2010induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nanotechnology Approaches to Biology &gt; Nanoscale Systems in Biology<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nanotechnology Approaches to Biology &gt; Cells at the Nanoscale<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Oncologic Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wnan.1896","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:17:51Z","timestamp":1684221471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Nanotechnology enabled radioprotectants to reduce space radiation\u2010induced reactive oxidative species"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-7254","authenticated-orcid":false,"given":"Balaashwin","family":"Babu","sequence":"first","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"},{"name":"Nanoscience Technology Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-1928","authenticated-orcid":false,"given":"Shreya","family":"Pawar","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"},{"name":"Burnett School of Biomedical Sciences, College of Medicine University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-4375","authenticated-orcid":false,"given":"Agastya","family":"Mittal","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"},{"name":"Burnett School of Biomedical Sciences, College of Medicine University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2615-6866","authenticated-orcid":false,"given":"Elayaraja","family":"Kolanthai","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-4229","authenticated-orcid":false,"given":"Craig J.","family":"Neal","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4543-4756","authenticated-orcid":false,"given":"Melanie","family":"Coathup","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-3344","authenticated-orcid":false,"given":"Sudipta","family":"Seal","sequence":"additional","affiliation":[{"name":"Advanced Materials Processing and Analysis Center, Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"},{"name":"College of Medicine, Nanoscience Technology Center University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2018.1536062"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-018-0538-z"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/frspt.2020.00001"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060107"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2019.108901"},{"key":"e_1_2_14_7_1","volume-title":"Farr's physics for medical imaging","author":"Allisy\u2010Roberts P. 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