{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:26:15Z","timestamp":1791408375622,"version":"4.3.3"},"reference-count":237,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["AntiBacCat\/031B1153A"],"award-info":[{"award-number":["AntiBacCat\/031B1153A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["Heart2.0\/031B1154B"],"award-info":[{"award-number":["Heart2.0\/031B1154B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["101115545"],"award-info":[{"award-number":["101115545"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs Nanomed Nanobiotechnol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Biomaterial\u2010associated infections (BAIs) pose significant challenges in modern medical technologies, being a major postoperative complication and leading cause of implant failure. These infections significantly risk patient health, resulting in prolonged hospitalization, increased morbidity and mortality rates, and elevated treatment expenses. This comprehensive review examines the mechanisms driving bacterial adhesion and biofilm formation on biomaterial surfaces, offering an in\u2010depth analysis of current antimicrobial strategies for preventing BAIs. We explore antimicrobial\u2010eluting biomaterials, contact\u2010killing surfaces, and antifouling coatings, emphasizing the application of antifouling polymer brushes on medical devices. Recent advancements in multifunctional antimicrobial biomaterials, which integrate multiple mechanisms for superior protection against BAIs, are also discussed. By evaluating the advantages and limitations of these strategies, this review aims to guide the design and development of highly efficient and biocompatible antimicrobial biomaterials. We highlight potential design routes that facilitate the transition from laboratory research to clinical applications. Additionally, we provide insights into the potential of synthetic biology as a novel approach to combat antimicrobial resistance. This review aspires to inspire future research and innovation, ultimately improving patient outcomes and advancing medical device technology.<\/jats:p>","DOI":"10.1002\/wnan.2018","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T07:15:28Z","timestamp":1733814928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Advanced Antibacterial Strategies for Combatting Biomaterial\u2010Associated Infections: A Comprehensive Review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-5918","authenticated-orcid":false,"given":"Esra","family":"Kasapgil","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering and Architecture Bakircay University  Izmir Turkey"},{"name":"Bioinspired Interactive Materials and Protocellular Systems Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-1340","authenticated-orcid":false,"given":"Manuela","family":"Garay\u2010Sarmiento","sequence":"additional","affiliation":[{"name":"DWI\u2010Leibniz Institute for Interactive Materials  Aachen Germany"},{"name":"Department of Biotechnology RWTH Aachen University  Aachen Germany"},{"name":"Department of Chemical and Biological Engineering BioFrontiers Institute, University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-0840","authenticated-orcid":false,"given":"C\u00e9sar","family":"Rodriguez\u2010Emmenegger","sequence":"additional","affiliation":[{"name":"Bioinspired Interactive Materials and Protocellular Systems Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST)  Barcelona Spain"},{"name":"DWI\u2010Leibniz Institute for Interactive Materials  Aachen Germany"},{"name":"Catalan Institution for Research and Advanced Studies (ICREA)  Barcelona Spain"},{"name":"Biomedical Research Networking, Center in Bioengineering, Biomaterials and Nanomedicine The Institute of Health Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c23119"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/3527603824"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00159"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12051195"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11693\u2010010\u20109066\u2010z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0019-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja026607s"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9ra10018k"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202300324"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S379502"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b01445"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201012149\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.03.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202000095"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202102359"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15102399"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1745"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1944"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010013\u20101079\u20104"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.200800720"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200334"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00512"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2021.100127"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.089"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13030086"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14059906"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c08068"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.063"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0mh00088d"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01369b"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings12101462"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialsau.2c00040"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.202101288"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b02527"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2014.06.075"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201900847"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12750"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071259"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b10029"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM01924C"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16159"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122465"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010022\u201000326\u2010x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37630"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0000000000000232"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/B210143M"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202300306"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b03908"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2019.1706550"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111820"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010023\u201000463\u20104"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2019.01.038"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202106656"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010201"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/14686996.2017.1348872"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.10.041"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.57.827"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.7150\/jbji.16934"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13233\u2010013\u20101142\u20102"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_113_16"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2022.101430"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170116122322"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010012\u20104628\u20105"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b01322"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121127"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01320"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b09804"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.2147\/idr.S209881"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802724"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27616"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppl.13938"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/la000736"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja045664d"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.3c03237"},{"key":"e_1_2_10_76_1","volume-title":"Intermolecular and Surface Forces","author":"Israelachvili J. N.","year":"2011"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b10886"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn302367m"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c00422"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.125609"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200901407"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2023.108028"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2023.158214"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2018.09.064"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01487"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.130076"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2014.01.026"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.036"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp993359m"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500252"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02349"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00065"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13202799"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200801523"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14996"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b03536"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c21672"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.3281"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00213"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201500322"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010022\u201006650\u2010x"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20092"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00330"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5012"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11038-7_8"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3020"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.09.052"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411680"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c07445"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm00255k"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coco.2022.101134"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020449"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c17697"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b18928"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c17498"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202201106"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201908855"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/ab5000578"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966\u2010842X(00)01913\u20102"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200281t"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201505522"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB01302G"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.02.059"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.1c00125"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010019\u20100058\u20108"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colcom.2023.100717"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201700359"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c01079"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings10020139"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202201425"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408699991279240"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.03.082"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c13098"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2022.132476"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149043"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202100051"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c17915"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103753"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01671K"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11768"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.12.046"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.4999786"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213714"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2617"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909313"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00910"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703000913"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.01.028"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202201055"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc4004469"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801248"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2006.139"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4916"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201100189"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201100425"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201200171"},{"key":"e_1_2_10_157_1","first-page":"1","volume-title":"A Modern Approach to Biofilm\u2010Related Orthopaedic Implant Infections: Advances in Microbiology, Infectious Diseases and Public Health","author":"Roman\u00f2 C. L.","year":"2017"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150075"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211701"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.10.013"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1170418"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1177\/22808000211040304"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201054477\u2010z"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics7040093"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/la204777x"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac054"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2766953"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100158"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34471-9_5"},{"key":"e_1_2_10_170_1","volume-title":"Point Prevalence Survey of Healthcare\u2010Associated Infections and Antimicrobial Use in European Acute Care Hospitals","author":"Suetens C.","year":"2024"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2023.108060"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10070752"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201401289"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020466"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11101417"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.12.007"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9649"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34661"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2023.130229"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111143098"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb4920"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings13061095"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2017.07.030"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00344"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm701293g"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colcom.2021.100560"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/syst.202100009"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15492"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.3844\/crdsp.2019.1.17"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284\u2010015\u20100834\u20106"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201009378\u20104"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2021.106609"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200617"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr06009g"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904436"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings12101469"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c21310"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b09879"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212739"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2024.108441"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.08.014"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202300434"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200025"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10447"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010015\u20105532\u20101"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202400004"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03528"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.7b03132"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100877"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c02150"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003774\u2010y"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201048006\u20109"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212544"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.112947"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041188"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127680"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128685"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8tb01918e"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2022.111481"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20880j"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242\u2010021\u201000133\u20108"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.202101053"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112878"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300746"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c04895"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03020"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2023.10.059"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra40497h"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b01060"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b00322"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c01694"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9MH00976K"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2023.107599"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208824"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010021\u201000429\u20103"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765\u2010023\u201000297\u20101"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000505"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.5640"}],"container-title":["WIREs Nanomedicine and Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T08:26:08Z","timestamp":1739262368000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wnan.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":237,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/wnan.2018"],"URL":"https:\/\/doi.org\/10.1002\/wnan.2018","archive":["Portico"],"relation":{},"ISSN":["1939-5116","1939-0041"],"issn-type":[{"value":"1939-5116","type":"print"},{"value":"1939-0041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2018"}}