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Current therapies are limited by nonspecific biodistribution and inadequate drug delivery to HSCs. Nanosystems engineered for active HSC targeting offer a promising approach to overcome fibrotic barriers\u2014including capillarized sinusoids and dense ECM\u2014through strategies such as receptor\u2010specific ligand modification, RNA\u2010based gene silencing, and multifunctional combinatorial therapies. These platforms enable precise modulation of HSC activation and ECM remodeling, promoting fibrosis regression while sparing healthy tissue. Despite promising preclinical outcomes, key challenges remain in biosafety, scalable fabrication, and clinical validation. Advancements in HSC\u2010specific nanotherapeutics hold transformative potential for reversing liver fibrosis and restoring hepatic function.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Nanotechnology Approaches to Biology &gt; Nanoscale Systems in Biology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wnan.70046","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:15:36Z","timestamp":1767345336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Precision Targeting of Hepatic Stellate Cells: Nanotherapeutic Strategies for Liver Fibrosis 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