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Despite advances in stem cell therapy, biomaterial scaffolds, and neuromodulation, recovery after spinal cord injury (SCI) is limited by a hostile post\u2010injury microenvironment marked by chronic inflammation, glial scarring, and extracellular matrix (ECM) stiffening. This Perspective proposes nanoengineered niclosamide, a repurposable multi\u2010pathway modulator, as a strategy to reprogram this niche. By attenuating NF\u2010\u03baB\/STAT3\u2013driven inflammation, suppressing fibrotic signaling, and reducing ECM rigidity, nanoengineered niclosamide may synergize with scaffold\u2010 and stimulation\u2010based approaches, highlighting microenvironmental modulation as a realistic path forward for SCI repair.<\/jats:p>","DOI":"10.1002\/wnan.70054","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:51:53Z","timestamp":1771833113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanoengineered Niclosamide as a Microenvironment Modulator for Spinal Cord Regeneration: A Hypothetical Roadmap Toward Brain\/Head Transplant Feasibility"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-0563","authenticated-orcid":false,"given":"N.","family":"Sanoj Rejinold","sequence":"first","affiliation":[{"name":"Intelligent Nanohybrid Materials Laboratory (INML), Department of Chemistry, College of Science and Technology Dankook University  Cheonan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-1103","authenticated-orcid":false,"given":"Geun\u2010woo","family":"Jin","sequence":"additional","affiliation":[{"name":"R&amp;D Center Hyundai Bioscience Co. 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