{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:48Z","timestamp":1782388188084,"version":"3.54.5"},"reference-count":123,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs Nanomed Nanobiotechnol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Recently, nano\u2010scale delivery approaches have been a field of focus to improve the limitations regarding current traditional delivery systems of phytochemicals to treat age\u2010related disorders. Nanotechnology can help to overcome both the large and small\u2010scale barriers associated with traditional drug and vitamin delivery techniques, such as poor biodistribution, instability, and intracellular trafficking, through cell\u2010targeting and other methods. The main forms of nano\u2010drug delivery systems can be classified under lipid\u2010based nanocarrier systems, polymer\u2010based nanocarrier systems, and inorganic carriers. This report focuses on the former two by presenting a comparative review of the advantages and disadvantages of each platform for the oral delivery of phytochemical\u2010encapsulated drugs to treat age\u2010related disorders. Nano\u2010drug delivery systems were found to increase the anti\u2010aging activities of curcumin, fisetin, quercetin, and astaxanthin. A variety of in\u00a0vivo and in\u00a0vitro studies show that nano\u2010scale encapsulation methods have the potential to improve the delivery and bioactivity of anti\u2010aging phytochemicals.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Biology\u2010Inspired Nanomaterials &gt; Lipid\u2010Based Structures<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Nanotechnology Approaches to Biology &gt; Nanoscale Systems in Biology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  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