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While conventional pharmacotherapies form the cornerstone of RA management, their efficacy is often limited by suboptimal therapeutic outcomes and severe systemic toxicity. In this context, stimuli\u2010responsive nanoplatforms (SR\u2010NPs) have emerged as a promising approach for precision treatment of RA, enabling on\u2010demand drug release triggered by disease\u2010specific endogenous (e.g., pH, ROS, enzymes, GSH, hypoxia) or exogenous (e.g., light, ultrasound, magnetic fields, heat) cues. This review provides a systematic overview of the cutting\u2010edge applications of SR\u2010NPs, categorizing them into endogenous (single\u2010 and multi\u2010stimuli), exogenous (single\u2010 and multi\u2010stimuli), and hybrid endogenous\u2010exogenous (e.g., ROS\/pH\/light, GSH\/heat) responsive systems. We critically evaluate the design principles, targeting mechanisms, therapeutic payloads, and performance of each category in preclinical RA models. Our analysis reveals that endogenous systems leverage the pathological microenvironment for disease\u2010dependent actuation, exogenous platforms offer tunable spatiotemporal control, while hybrid designs represent an emerging trend toward synergistic and programmable precision. Despite promising advances in enhanced joint retention and effective inflammation suppression, key challenges concerning stimulus heterogeneity, long\u2010term biocompatibility, and clinical translation remain to be addressed. Taken together, this work underscores the evolution of SR\u2010NPs into intelligent and multifaceted therapeutics, thereby providing a potential framework for personalized RA management.<\/jats:p>","DOI":"10.1002\/wnan.70073","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:13:35Z","timestamp":1786079615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stimuli\u2010Responsive Nanoplatforms for Precision Intervention in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6238-9878","authenticated-orcid":false,"given":"Ao","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Mechanism and Quality Research in Chinese Medicine Macau University of Science and Technology  Macao 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