{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:16:24Z","timestamp":1788333384882,"version":"build-2803163510"},"reference-count":210,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32601935"],"award-info":[{"award-number":["32601935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs Nanomed Nanobiotechnol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that places an increasing burden on patients, caregivers, and healthcare systems worldwide. Current disease\u2010modifying therapies (DMTs) are limited by high costs, complex administration, and reliance on advanced biomarker infrastructure, highlighting the shortcomings of existing treatment paradigms. These limitations have sparked growing interest in gene\u2010 and nucleic acid\u2013based interventions as upstream strategies to modify AD pathogenesis. Among these, small interfering RNA (siRNA) is especially compelling because it can be rationally programmed, directed at multiple molecular pathways, and paired with rapidly evolving delivery technologies. However, the clinical translation of siRNA therapies for AD is still constrained by challenges in brain\u2010targeted delivery, safety, and sustained efficacy. In this review, we summarize current concepts in AD pathology, highlight recent clinical and translational advances, and critically assess emerging brain\u2010targeted siRNA delivery platforms and their key bottlenecks. Within a precision\u2010medicine framework, brain\u2010targeted siRNA offers the possibility of aligning patient selection, molecular targets, and delivery strategies with biomarker\u2010defined AD endotypes. We discuss both the therapeutic promise and the realistic limitations of siRNA\u2010based approaches for AD, outline priorities for future development, and identify key gaps that must be addressed to enable meaningful clinical implementation.<\/jats:p>","DOI":"10.1002\/wnan.70076","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:57:48Z","timestamp":1788332268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain\u2010Targeting\n                    <scp>siRNA<\/scp>\n                    Delivery to Tackle Alzheimer's Disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Qingshan","family":"Yang","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouchun","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7352-700X","authenticated-orcid":false,"given":"Tianran","family":"Chai","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"},{"name":"Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjie","family":"Tang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Fan","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Analytical and Testing Center, School of Life Science, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Provincial Engineering Research Center for Precision Diagnosis and Personalized Treatment of Rectal Cancer, Henan Provincial International Joint Laboratory for Sepsis Research, the Second Clinical Medicine School, Henan University  Kaifeng Henan China"},{"name":"School of Biomedical Engineering, University of Technology Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-1062","authenticated-orcid":false,"given":"Meng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010Nanomedicine, Henan International Joint Laboratory of Nanobiomedicine, School of Life Sciences, Henan University  Kaifeng Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn900201e"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100205\u20100"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1807"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165584"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010025\u201002419\u20100"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u2010628406\/v1"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.94206"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168979"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi2245"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae368"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001024\u2010z"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120614"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057488\u20100"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201048461\u20104"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005593"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14100960"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010022\u201001334\u2010x"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.573324"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201004811\u2010x"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.11.2776"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400168"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9845459"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041355\u2010x"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9867230"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201020568\u2010y"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.082650"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.084521"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz70859_097989"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.10.001"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010018\u20100013\u2010z"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25978"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.029"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7bm00334j"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20230178"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.09.015"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.054"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002607"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000951\u2010z"},{"key":"e_1_2_18_45_1","unstructured":"FDA Grants Accelerated Approval for Alzheimer's Drug.2021.https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010grants\u2010accelerated\u2010approval\u2010alzheimers\u2010drug."},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae100"},{"key":"e_1_2_18_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042071"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.791416"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200513122357"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u2010291x(84)91209\u20109"},{"key":"e_1_2_18_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_18_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20102236(93)90078\u2010z"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092844"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010024\u201001883\u20104"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.10.005"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf7390"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002972\u2010w"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fddev.2024.1360302"},{"key":"e_1_2_18_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001775\u2010x"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.08.013"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505846"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2003.5.1\/hhippius"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205174"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4na00028e"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124368"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101769\u2010z"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115665232357160250123113148"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14020110"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr\u2010d\u201024\u201000303"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1796628"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010190090"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad159"},{"key":"e_1_2_18_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010021\u201000399\u2010x"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044569\u20106"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057108\u2010x"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001148\u20100"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.04.019"},{"key":"e_1_2_18_81_1","doi-asserted-by":"publisher","DOI":"10.21037\/sci.2017.08.07"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.103028"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.03.002"},{"key":"e_1_2_18_85_1","doi-asserted-by":"crossref","unstructured":"Koksalmis G. H. B.Soykan L. J.Brattain et\u00a0al.2025.\u201cArtificial Intelligence for Personalized Prediction of Alzheimer's Disease Progression: A Survey of Methods Data Challenges and Future Directions.\u201darXiv preprint arXiv:2504.21189.https:\/\/doi.org\/10.1002\/wics.70043.","DOI":"10.1002\/wics.70043"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.3410\/f.735170868.793558625"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3432\u201004.2004"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001745\u20100"},{"key":"e_1_2_18_89_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.focus17620"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2011.07478.x"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910357"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u201000435\u2010y"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.940999"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08126"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1515\/nipt\u20102024\u20100013"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010025\u201000503\u20107"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4bm00878b"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300215120"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306675"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004529\u20106"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010022\u201001252\u20100"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.12.002"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01024"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130638"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.3410\/f.725982642.793570284"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202314354"},{"key":"e_1_2_18_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.001"},{"key":"e_1_2_18_108_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1775724"},{"key":"e_1_2_18_109_1","doi-asserted-by":"publisher","DOI":"10.7554\/elife.100968.3"},{"key":"e_1_2_18_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.689098"},{"key":"e_1_2_18_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.11.010"},{"key":"e_1_2_18_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hsr.2024.100157"},{"key":"e_1_2_18_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067916\u20108"},{"key":"e_1_2_18_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010021\u201000545\u20101"},{"key":"e_1_2_18_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_18_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3462"},{"key":"e_1_2_18_117_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2589276"},{"key":"e_1_2_18_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1572771"},{"key":"e_1_2_18_119_1","doi-asserted-by":"crossref","unstructured":"Miller R. J.Paquette A.Barker et\u00a0al.2024.\u201cPreventing Acute Neurotoxicity of CNS Therapeutic Oligonucleotides With the Addition of ca2+ and Mg2+ in the Formulation.\u201dbioRxiv: The Preprint Server for Biology no.: 2024.2006.2006.597639.https:\/\/doi.org\/10.1101\/2024.06.06.597639.","DOI":"10.1016\/j.omtn.2024.102359"},{"key":"e_1_2_18_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/colloids7010023"},{"key":"e_1_2_18_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2005.06.003"},{"key":"e_1_2_18_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2211999119"},{"key":"e_1_2_18_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116691"},{"key":"e_1_2_18_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx818"},{"key":"e_1_2_18_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.029"},{"key":"e_1_2_18_126_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010061010\u2010113613"},{"key":"e_1_2_18_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076638"},{"key":"e_1_2_18_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13092108"},{"key":"e_1_2_18_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2022.03.001"},{"key":"e_1_2_18_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1459134"},{"key":"e_1_2_18_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1946"},{"key":"e_1_2_18_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197\u20104580(02)00081\u20107"},{"key":"e_1_2_18_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102711d"},{"key":"e_1_2_18_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.10.010"},{"key":"e_1_2_18_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010014\u20101379\u20107"},{"key":"e_1_2_18_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.09.008"},{"key":"e_1_2_18_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14176047"},{"key":"e_1_2_18_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309225"},{"key":"e_1_2_18_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010022\u201000359\u20103"},{"key":"e_1_2_18_140_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010150040"},{"key":"e_1_2_18_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11010032"},{"key":"e_1_2_18_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.01.031"},{"key":"e_1_2_18_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c05527"},{"key":"e_1_2_18_144_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308719"},{"key":"e_1_2_18_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002571117"},{"key":"e_1_2_18_146_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010200666110\u201000015"},{"key":"e_1_2_18_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010023\u201001374\u20100"},{"key":"e_1_2_18_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00271"},{"key":"e_1_2_18_149_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2024.106"},{"key":"e_1_2_18_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105979"},{"key":"e_1_2_18_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1383163"},{"key":"e_1_2_18_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110921"},{"key":"e_1_2_18_153_1","doi-asserted-by":"publisher","DOI":"10.1049\/mnl.2017.0457"},{"key":"e_1_2_18_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.012"},{"key":"e_1_2_18_155_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15013"},{"key":"e_1_2_18_156_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"e_1_2_18_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.04672.x"},{"key":"e_1_2_18_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.042"},{"key":"e_1_2_18_159_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.025886"},{"key":"e_1_2_18_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"e_1_2_18_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.03.006"},{"key":"e_1_2_18_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20240388"},{"key":"e_1_2_18_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010024\u201000715\u2010x"},{"key":"e_1_2_18_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114018"},{"key":"e_1_2_18_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.15"},{"key":"e_1_2_18_166_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_18_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403473"},{"key":"e_1_2_18_168_1","doi-asserted-by":"crossref","unstructured":"Sorets A. G. K. R.Schwensen N.Francini et\u00a0al.2024.\u201cLipid\u2010siRNA Conjugate Accesses Perivascular Transport and Achieves Durable Knockdown Throughout the Central Nervous System.\u201dbioRxiv no.https:\/\/doi.org\/10.1101\/2024.06.09.598079.","DOI":"10.1101\/2024.06.09.598079"},{"key":"e_1_2_18_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139652"},{"key":"e_1_2_18_170_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S506793"},{"key":"e_1_2_18_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20240112"},{"key":"e_1_2_18_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.11.030"},{"key":"e_1_2_18_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_2_18_174_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.3.317"},{"key":"e_1_2_18_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071597"},{"key":"e_1_2_18_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12204"},{"key":"e_1_2_18_177_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010200463"},{"key":"e_1_2_18_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101326\u20109\u201048"},{"key":"e_1_2_18_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1447953"},{"key":"e_1_2_18_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050919"},{"key":"e_1_2_18_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201061355\u20103"},{"key":"e_1_2_18_182_1","doi-asserted-by":"publisher","DOI":"10.17879\/freeneuropathology\u20102020\u20103025"},{"key":"e_1_2_18_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029552\u20106"},{"key":"e_1_2_18_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010024\u201002487\u20107"},{"key":"e_1_2_18_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1673"},{"key":"e_1_2_18_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.034"},{"key":"e_1_2_18_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_18_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.06.127"},{"key":"e_1_2_18_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116038"},{"key":"e_1_2_18_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.18"},{"key":"e_1_2_18_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001481\u2010w"},{"key":"e_1_2_18_192_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1214450"},{"key":"e_1_2_18_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002312\u2010w"},{"key":"e_1_2_18_194_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652321405140926160602"},{"key":"e_1_2_18_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.035"},{"key":"e_1_2_18_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010024\u201005225\u2010z"},{"key":"e_1_2_18_197_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26136271"},{"key":"e_1_2_18_198_1","doi-asserted-by":"publisher","DOI":"10.16476\/j.pibb.2023.0109"},{"key":"e_1_2_18_199_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.4c00659"},{"key":"e_1_2_18_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.04.010"},{"key":"e_1_2_18_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202203182"},{"key":"e_1_2_18_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427\u2010020\u20100216\u20109"},{"key":"e_1_2_18_203_1","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.nrr\u2010d\u201024\u201000695"},{"key":"e_1_2_18_204_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57078"},{"key":"e_1_2_18_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1623"},{"key":"e_1_2_18_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1696"},{"key":"e_1_2_18_207_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14098"},{"key":"e_1_2_18_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.01.008"},{"key":"e_1_2_18_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903277"},{"key":"e_1_2_18_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.029"},{"key":"e_1_2_18_211_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc7031"}],"container-title":["WIREs Nanomedicine and Nanobiotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wnan.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wnan.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:57:51Z","timestamp":1788332271000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wnan.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":210,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/wnan.70076"],"URL":"https:\/\/doi.org\/10.1002\/wnan.70076","archive":["Portico"],"relation":{},"ISSN":["1939-5116","1939-0041"],"issn-type":[{"value":"1939-5116","type":"print"},{"value":"1939-0041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70076"}}