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The intrinsic intricacy and heterogeneity of these signaling pathways require innovative therapeutic approaches that allow precise immunomodulation while alleviating systemic toxicity. Lipid\u2010based nanocarriers (LBNCs), including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, have emerged as transformative platforms to deliver a variety of therapeutic agents. The clinical maturity of these systems, catalyzed by the global success of lipid\u2010based RNA vaccines, has established an initial safety and scalability of this framework, which is now being transitioned toward chronic inflammatory management. This review critically evaluates the structure\u2013function relationships of LBNCs, examining how specific physicochemical attributes dictate their interaction with inflamed tissues. We analyze the molecular mechanisms by which LBNCs' architecture modulates key inflammatory regulators, such as cytokine networks and oxidative pathways, to achieve superior therapeutic control. Furthermore, we scrutinize the strategic selection of delivery routes and their direct impact on site\u2010specific biodistribution and patient compliance. By addressing current bottlenecks in long\u2010term immunocompatibility and regulatory characterization, this review provides a roadmap for engineering the next generation of bio\u2010responsive anti\u2010inflammatory nanomedicines. Collectively, these insights position LBNCs as a transformative paradigm for refining the precision and efficacy of modern anti\u2010inflammatory therapy.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Biology\u2010Inspired Nanomaterials &gt; Lipid\u2010Based Structures.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wnan.70081","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:15:52Z","timestamp":1791771352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid\u2010Based Nanotherapeutics for Inflammatory Disorders: Current Progress and Future 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