{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:29:35Z","timestamp":1791674975258,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,5]],"date-time":"2016-06-05T00:00:00Z","timestamp":1465084800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["32-50881.97"],"award-info":[{"award-number":["32-50881.97"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World Psychiatry"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>In the prospective long\u2010term Zurich study, we re\u2010examined the hypothesized association between mental health problems in women and the transition through menopausal stages. One hundred sixty\u2010eight women from a population\u2010based Swiss community cohort were prospectively followed up from age 21 to 50. At age 50, the occurrence of hot flushes\/night sweats and sleep disturbances was significantly more frequent in peri\u2010 and post\u2010menopausal women. Irritability\/nervousness was increased only in peri\u2010menopausal women, but that association was accounted for by neuroticism trait scores at age 30. Transitions to peri\u2010 or post\u2010menopause were not related to changes in either the prevalence rates of DSM major depressive episode or anxiety disorders, or the course of psychopathological syndromes as assessed by the Symptom Checklist 90 \u2010 Revised. The null associations held when adjusting for duration of reproductive period or age at menopause. Preceding mental health problems between ages 21 and 41, increased neuroticism trait scores at age 30, and concurrent psychosocial distress were significantly related to mental health problems occurring between ages 41 and 50. Depending upon the cut\u2010off point that was chosen, the arbitrary dichotomization of a continuous depression outcome produced spurious associations with the menopausal transition. We conclude that mental health problems between ages 41 and 50 are probably not directly related to the menopausal transition, and that previously reported associations could be false positives due to inadequate dichotomizations, reporting bias, undisclosed multiple adjustments or overfitting.<\/jats:p>","DOI":"10.1002\/wps.20319","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T04:44:31Z","timestamp":1465188271000},"page":"146-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Does menopausal transition really influence mental health? Findings from the prospective long\u2010term <scp>Z<\/scp>urich study"],"prefix":"10.1002","volume":"15","author":[{"given":"Wulf","family":"R\u00f6ssler","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics University of Zurich Zurich Switzerland"},{"name":"Institute of Psychiatry, Laboratory of Neuroscience (LIM 27), University of S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladeta","family":"Ajdacic\u2010Gross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Riecher\u2010R\u00f6ssler","sequence":"additional","affiliation":[{"name":"University of Basel Psychiatric Clinics, Center for Gender Research and Early Detection Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Angst","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatics University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Department of Applied Psychology Zurich University of Applied Sciences Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60346-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181db9f8b"},{"key":"e_1_2_6_5_1","first-page":"565","article-title":"The forthcoming role of treatment with oestrogens in mental health","volume":"137","author":"Riecher\u2010R\u00f6ssler A","year":"2007","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(94)90099-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(01)00326-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023421128141"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181450fc2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199911000-00006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130701611267"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.01.034"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.1.62"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.385"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171100016X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.375"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2006.0138"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.05.014"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.55"},{"key":"e_1_2_6_20_1","first-page":"53","article-title":"Depression and gender: implications for primary care","volume":"3","author":"Weissman MM.","year":"2000","journal-title":"J Gend Specif Med"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702613505532"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00087"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015309"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704003563"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.114.1.96"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001966"},{"key":"e_1_2_6_27_1","volume-title":"Symptom Checklist 90, R\u2010Version Manual I: scoring, administration, and procedures for the SCL\u201090","author":"Derogatis LR.","year":"1977"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432878"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00006278"},{"key":"e_1_2_6_30_1","first-page":"81","volume-title":"Handbook of psychiatric measures","author":"Derogatis LR.","year":"2000"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008931926181"},{"key":"e_1_2_6_32_1","volume-title":"Revidierte Fassung FPI\u2010R und teilweise ge\u00e4nderte Fassung FPI\u2010A1. 4., revidierte Auflage","author":"Fahrenberg J","year":"1984"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(86)90055-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716000210"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S204579601500027X"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531734"},{"key":"e_1_2_6_37_1","volume-title":"Applied longitudinal data analysis for epidemiology: a practical guide","author":"Twisk JWR.","year":"2003"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0013164496056005002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2013.04.003"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0554"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.5.857"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034151"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.12.2238"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(92)90006-P"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-240X(199604)19:2<111::AID-NUR3>3.0.CO;2-P"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091532"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.7.1.19"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2425"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2331"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199209000-00009"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991036"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.3579"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.6.495"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.2.277"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2653"},{"key":"e_1_2_6_56_1","article-title":"Estrogen\u2010based therapies and depression in women who naturally enter the menopause before population average: a comment on Georgakis et al 2016","author":"Hengartner MP.","journal-title":". JAMA Psychiatry"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.49.12.997"},{"key":"e_1_2_6_58_1","article-title":"Big Five personality traits and the General Factor of Personality as moderators of stress and coping reactions following an emergency alarm on a Swiss university campus","author":"Hengartner MP","journal-title":"Stress Health"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.631"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-3506.2004.00265.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.12.010"}],"container-title":["World Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwps.20319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wps.20319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:51:32Z","timestamp":1695574292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/wps.20319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/wps.20319"],"URL":"https:\/\/doi.org\/10.1002\/wps.20319","archive":["Portico"],"relation":{},"ISSN":["1723-8617","2051-5545"],"issn-type":[{"value":"1723-8617","type":"print"},{"value":"2051-5545","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}