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This has been extended, more recently, to include studies of cumulative effects, of interactions with other factors, of specific effects, and of putative biological and psychological mechanisms. In this paper we evaluate this research and highlight the remaining methodological issues and gaps that temper, but do not dismiss, conclusions about the causal role of childhood adversity. We also consider the emerging work on cumulative, synergistic, and specific effects and on mechanisms; and discuss the broader implications of this line of research for our understanding of psychosis. We conclude that the current balance of evidence is that childhood adversities \u2013 particularly exposure to multiple adversities involving hostility and threat \u2013 do, in some people, contribute to the onset of psychotic experiences and psychotic disorders.<\/jats:p>","DOI":"10.1002\/wps.20330","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T04:44:31Z","timestamp":1465188271000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":230,"title":["Childhood adversities and psychosis: evidence, challenges, implications"],"prefix":"10.1002","volume":"15","author":[{"given":"Craig","family":"Morgan","sequence":"first","affiliation":[{"name":"Society and Mental Health Research Group, Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, King's College London, London, UK; National Institute for Health Research (NIHR) 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