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We aimed to investigate the validity and utility of general and specific symptom dimensions of psychosis cutting across schizophrenia, schizoaffective disorder and bipolar I disorder with psychosis. Multidimensional item\u2010response modeling was conducted on symptom ratings of the Positive and Negative Syndrome Scale, Young Mania Rating Scale, and Montgomery\u2010\u00c5sberg Depression Rating Scale in the multicentre Bipolar\u2010Schizophrenia Network on Intermediate Phenotypes (B\u2010SNIP) consortium, which included 933 patients with a diagnosis of schizophrenia (N=397), schizoaffective disorder (N=224), or bipolar I disorder with psychosis (N=312). A bifactor model with one general symptom dimension, two distinct dimensions of non\u2010affective and affective psychosis, and five specific symptom dimensions of positive, negative, disorganized, manic and depressive symptoms provided the best model fit. There was further evidence on the utility of symptom dimensions for predicting B\u2010SNIP psychosis biotypes with greater accuracy than categorical DSM diagnoses. General, positive, negative and disorganized symptom dimension scores were higher in African American vs. Caucasian patients. Symptom dimensions accurately classified patients into categorical DSM diagnoses. This study provides evidence on the validity and utility of transdiagnostic symptom dimensions of psychosis that transcend traditional diagnostic boundaries of psychotic disorders. Findings further show promising avenues for research at the interface of dimensional psychopathological phenotypes and basic neurobiological dimensions of psychopathology.<\/jats:p>","DOI":"10.1002\/wps.20607","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T09:40:36Z","timestamp":1546422036000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Transdiagnostic dimensions of psychosis in the Bipolar\u2010Schizophrenia Network on Intermediate Phenotypes (B\u2010SNIP)"],"prefix":"10.1002","volume":"18","author":[{"given":"Ulrich","family":"Reininghaus","sequence":"first","affiliation":[{"name":"Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg Mannheim Germany"},{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience Maastricht University Maastricht The Netherlands"},{"name":"Centre for 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