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However, anxiety and related disorders are not only frequently comorbid, but each is also quite heterogeneous; thus\u00a0diagnostic manuals provide only a first step towards formulating a management plan, and the development of additional decision support tools for the treatment of anxiety conditions is needed. This paper aims to describe systematically important domains that are relevant to the personalization of management of anxiety and related disorders in adults. For each domain, we summarize the available research evidence and review the relevant assessment instruments, paying special attention to their suitability for use in routine clinical practice. We emphasize areas where the available evidence allows the clinician to personalize the management of anxiety conditions, and we point out key unmet needs. Overall, the evidence suggests that we are becoming able to move from simply recommending that anxiety and related disorders be treated with selective serotonin reuptake inhibitors, cognitive\u2010behavioral therapy, or their combination, to a more complex approach which emphasizes that the clinician has a broadening array of management modalities available, and that the treatment of anxiety and related disorders can already be personalized in a number of important respects.<\/jats:p>","DOI":"10.1002\/wps.20919","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T03:16:40Z","timestamp":1631243800000},"page":"336-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management"],"prefix":"10.1002","volume":"20","author":[{"given":"Dan J.","family":"Stein","sequence":"first","affiliation":[{"name":"South African Medical Research Council Unit on Risk &amp; Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G.","family":"Craske","sequence":"additional","affiliation":[{"name":"Department of Psychology and Department of Psychiatry and Biobehavioral Sciences University of California  Los Angeles (UCLA), Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara O.","family":"Rothbaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Emory University  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine University of Southampton, and Southern Health NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi A.","family":"Fineberg","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences University of Hertfordshire, and Hertfordshire Partnership University NHS Foundation Trust  Hatfield UK"},{"name":"University of Cambridge Clinical Medical School  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karmel W.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Developmental Psychology, Department of Psychology Rijksuniversiteit Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine University of Southampton, and Southern Health NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Campania \u201cL. 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