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This paper reviews evidence on the validity and utility of the internalizing and somatoform spectra of HiTOP, which together provide support for an emotional dysfunction superspectrum. These spectra are composed of homogeneous symptom and maladaptive trait dimensions currently subsumed within multiple diagnostic classes, including depressive, anxiety, trauma\u2010related, eating, bipolar, and somatic symptom disorders, as well as sexual dysfunction and aspects of personality disorders. Dimensions falling within the emotional dysfunction superspectrum are broadly linked to individual differences in negative affect\/neuroticism. Extensive evidence establishes that dimensions falling within the superspectrum share genetic diatheses, environmental risk factors, cognitive and affective difficulties, neural substrates and biomarkers, childhood temperamental antecedents, and treatment response. The structure of these validators mirrors the quantitative structure of the superspectrum, with some correlates more specific to internalizing or somatoform conditions, and others common to both, thereby underlining the hierarchical structure of the domain. Compared to traditional diagnoses, the internalizing and somatoform spectra demonstrated substantially improved utility: greater reliability, larger explanatory and predictive power, and greater clinical applicability. Validated measures are currently available to implement the HiTOP system in practice, which can make diagnostic classification more useful, both in research and in the clinic.<\/jats:p>","DOI":"10.1002\/wps.20943","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T16:12:18Z","timestamp":1641917538000},"page":"26-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":255,"title":["Validity and utility of Hierarchical Taxonomy of Psychopathology (<scp>HiTOP<\/scp>): <scp>III<\/scp>. Emotional dysfunction superspectrum"],"prefix":"10.1002","volume":"21","author":[{"given":"David","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Psychology University of Notre Dame  South Bend IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly F.","family":"Levin\u2010Aspenson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika A.","family":"Waszczuk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Stony Brook University  Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Conway","sequence":"additional","affiliation":[{"name":"Department of Psychology Fordham University  Bronx NY 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