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In a previous meta\u2010analysis published in this journal, which was updated in 2018, we found evidence that the pooled effects for the two formats were equivalent in the treatment of psychiatric and somatic disorders, but the number of published randomized trials was relatively low (n=20). As this is a field that moves rapidly, the aim of the current study was to conduct an update of our systematic review and meta\u2010analysis of the clinical effects of ICBT vs. face\u2010to\u2010face CBT for psychiatric and somatic disorders in adults. We searched the PubMed database for relevant studies published from 2016 to 2022. The main inclusion criteria were that studies had to compare ICBT to face\u2010to\u2010face CBT using a randomized controlled design and targeting adult populations. Quality assessment was made using the Cochrane risk of bias criteria (Version 1), and the main outcome estimate was the pooled standardized effect size (Hedges\u2019 g) using a random effects model. We screened 5,601 records and included 11 new randomized trials, adding them to the 20 previously identified ones (total n=31). Sixteen different clinical conditions were targeted in the included studies. Half of the trials were in the fields of depression\/depressive symptoms or some form of anxiety disorder. The pooled effect size across all disorders was g=0.02 (95% CI: \u20130.09 to 0.14) and the quality of the included studies was acceptable. This meta\u2010analysis further supports the notion that therapist\u2010supported ICBT yields similar effects as face\u2010to\u2010face CBT.<\/jats:p>","DOI":"10.1002\/wps.21088","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:01:23Z","timestamp":1683738083000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":270,"title":["Therapist\u2010supported Internet\u2010based cognitive behaviour therapy yields similar effects as face\u2010to\u2010face therapy for psychiatric and somatic disorders: an updated systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Erik","family":"Hedman\u2010Lagerl\u00f6f","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Carlbring","sequence":"additional","affiliation":[{"name":"Department of Psychology Stockholm University Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Sv\u00e4rdman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen","family":"Riper","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuro\u2010 and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands"},{"name":"Department of Psychiatry Amsterdam Public Health Research Institute, Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Cuijpers","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuro\u2010 and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Department of Behavioural Sciences and Learning, and Department of Biomedical and Clinical Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02736-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20998"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002472"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.139"},{"key":"e_1_2_6_6_1","volume-title":"Generalised anxiety disorder and panic disorder (with or without agoraphobia) in adults","author":"National Institute for Health and Care Excellence","year":"2011"},{"key":"e_1_2_6_7_1","volume-title":"Depression in adults: recognition and management","author":"National Institute for Health and Care Excellence","year":"2015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-021815-093006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20151"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/16506073.2017.1401115"},{"key":"e_1_2_6_11_1","volume-title":"Cochrane handbook for systematic reviews of interventions. 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