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However, substantial improvements are still much needed, and many innovations of therapies are currently being developed. We review the current status of promising innovations to improve the outcomes and uptake of psychotherapies for mental disorders, discussing the largest and most recent meta\u2010analyses. Innovations are categorized into four domains: a) the digital field (including Internet\u2010based interventions in general; mobile interventions; serious games; virtual and augmented reality; prescription digital therapeutics; blended therapy; avatar therapy; and chatbots\/artificial intelligence\u2010generated conversational agents); b) personalized treatments (research on predictors and moderators in large randomized controlled trials; use of individual patient data meta\u2010analyses in personalization; machine learning approaches; personalized and modular therapies; and matching therapists to patients); c) new and improved therapies (cognitive bias modification; cognitive remediation; psychedelic\u2010assisted psychotherapies; transdiagnostic therapies; research on effective components through factorial trials and component network meta\u2010analyses; innovations in the understanding of the processes involved in psychotherapies, including research on common factors and the therapeutic alliance, and on the fidelity vs. flexibility question; research on prevention of adverse effects of therapies, the impact of increased session frequency or progress feedback on outcomes, and methodological innovations in trial designs); and d) dissemination and simplification of therapies (task sharing, digital interventions in low\u2010 and middle\u2010income countries; and single\u2010session interventions). These innovations vary in their maturity, from dozens of supporting trials to few or none. Methods to assess the strength of innovations suggest that no innovation will be a paradigm\u2010shifting \u201csilver bullet\u201d that dramatically increases treatment outcomes, but that progress will only be possible through multiple, incremental improvements.<\/jats:p>","DOI":"10.1002\/wps.70002","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:50:36Z","timestamp":1768459836000},"page":"4-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state\u2010of\u2010the\u2010art review"],"prefix":"10.1002","volume":"25","author":[{"given":"Pim","family":"Cuijpers","sequence":"first","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, WHO Collaborating Center for Research and Dissemination of Psychological Interventions Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"International Institute for Psychotherapy Babe\u0219\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Harrer","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, WHO Collaborating Center for Research and Dissemination of Psychological Interventions Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshi A.","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Kyoto University Office of Institutional Advancement and Communications  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"World mental health report: transforming mental 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