{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:26:37Z","timestamp":1790785597574,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["World Psychiatry"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Early intervention services (EIS) for psychosis have demonstrated superiority to usual care\/modular care (UC\/MC) until the end of their delivery. However, the maintenance effects of EIS care after transition to UC\/MC are less clear. We aimed to compare these effects vs. UC\/MC at least one year after the end of EIS care. This PRISMA and MOOSE\u2010compliant systematic review searched PubMed, EMBASE, PsycINFO and Web of Science databases and Cochrane Central Register of Reviews, without time or language restrictions. We included studies initially designed as randomized controlled trials (RCTs) comparing EIS vs. UC\/MC in patients with early\u2010phase psychosis, in which both the intervention and control groups were followed for at least 12 months after cessation of EIS care in the intervention group. Co\u2010primary outcomes were psychiatric hospitalization, duration of hospitalization, and drop\u2010out at the end of follow\u2010up (preferably 5 years post\u2010EIS initiation). Secondary outcomes were severity of total, positive and negative symptoms; quality of life, work involvement, remission, legal offences, antipsychotic use, and suicide attempts. We meta\u2010analyzed six RCTs with data from 13 papers, including 1,416 individuals (mean age: 23.9 years, females: 36.7%). After 2\u20103 years of receiving UC\/MC, subsequent to 2\u20103 years of EIS care or UC\/MC, individuals who originally received EIS care spent less days hospitalized than those continuing UC\/MC (n=5, standardized mean difference, SMD=0.128, 95% CI: 0.019\u20100.237, p=0.021). However, although we confirmed the superiority of EIS care to UC\/MC at the end of the intervention period (except for work involvement and legal offences), the two groups did not differ significantly at 2\u20103 years post\u2010EIS care regarding hospitalization, all\u2010cause drop\u2010out, quality of life; severity of total, positive and negative symptoms; work involvement, remission, legal offences, antipsychotic use, and suicide attempts. In summary, EIS care did not maintain its superiority over UC\/MC 2\u20103 years after its cessation across meta\u2010analyzable outcomes, except for duration of hospitalizations. These results support the need to further develop and potentially extend full or individualized EIS delivery.<\/jats:p>","DOI":"10.1002\/wps.70012","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:50:36Z","timestamp":1768459836000},"page":"95-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Do early intervention services for psychosis maintain their effects after transition to usual\/modular care? A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"25","author":[{"given":"Gonzalo","family":"Salazar de Pablo","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience King\u2019s College London  London UK"},{"name":"Child and Adolescent Mental Health Services South London and Maudsley NHS Foundation Trust  London UK"},{"name":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario \u201cG. 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