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Using comprehensive Swedish national register data, we located cases of 12 disorders within this space and examined how their genetic risk profiles varied as a function of sex, age at onset, and level of recurrence. Disorders segregated robustly into two clusters. Internalizing disorders were characterized by moderate genetic liability for MD and low liability for DUD, while externalizing disorders displayed substantial risk for both genetic dimensions. These patterns were replicated across regions of Sweden. Post\u2010traumatic stress disorder (PTSD) grouped with the internalizing cluster, whereas borderline personality disorder aligned with the externalizing group. Sex differences in genetic liability were common and frequently involved both axes: typically, the sex with the lower disorder prevalence carried higher genetic risk, with the most striking contrasts observed for alcohol use disorder (AUD) and DUD. Across most disorders, earlier age at onset was associated with elevated genetic liability, with particularly strong effects for AUD, MD and PTSD. Similarly, high level of recurrence consistently indexed increased genetic risk, often spanning both axes, with notable prominence for AUD, DUD, MD and PTSD. Taken together, these findings suggest that the genetic liabilities underlying psychiatric and substance use disorders are not fixed entities but vary systematically with key clinical features. Considering multiple genetic risks simultaneously provides an informative framework for understanding cross\u2010disorder relationships between psychiatric disorders.<\/jats:p>","DOI":"10.1002\/wps.70074","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:48:21Z","timestamp":1778831301000},"page":"278-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The typology of common psychiatric disorders as depicted by genetic maps: a study based on Swedish population\u2010based registers"],"prefix":"10.1002","volume":"25","author":[{"given":"Kenneth S.","family":"Kendler","sequence":"first","affiliation":[{"name":"Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University  Richmond VA USA"},{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond VA 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