{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:42:49Z","timestamp":1791434569177,"version":"4.3.3"},"reference-count":80,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs RNA"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p><jats:italic>Cryptococcus neoformans<\/jats:italic> is an environmental fungus that can cause severe disease in humans. <jats:italic>C. neoformans<\/jats:italic> encounters a multitude of stresses within the human host to which it must adapt in order to survive and proliferate. Upon stressful changes in the external milieu, <jats:italic>C. neoformans<\/jats:italic> must reprogram its gene expression to properly respond to and combat stress in order to maintain homeostasis. Several studies have investigated the changes that occur in response to these stresses to begin to unravel the mechanisms of adaptation in this organism. Here, we review studies that have explored stress\u2010induced changes in gene expression with a focus on host temperature adaptation. We compare global messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>) expression data compiled from several studies and identify patterns that suggest that orchestrated, transient responses occur. We also utilize the available expression data to explore the possibility of a common stress response that may contribute to cellular protection against a variety of stresses in <jats:italic>C.\u00a0neoformans<\/jats:italic>. In addition, we review studies that have revealed the significance of post\u2010transcriptional mechanisms of <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> regulation in response to stress, and discuss how these processes may contribute to adaptation and virulence.<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>RNA Turnover and Surveillance &gt; Turnover\/Surveillance Mechanisms<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Turnover and Surveillance &gt; Regulation of RNA Stability<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Development<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1219","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T23:32:09Z","timestamp":1391556729000},"page":"393-406","source":"Crossref","is-referenced-by-count":14,"title":["<scp>RNA<\/scp> biology and the adaptation of <i>Cryptococcus neoformans<\/i> to host temperature and stress"],"prefix":"10.1002","volume":"5","author":[{"given":"Amanda L. 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