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These efforts have led to the surprising recognition that although insect and vertebrate eyes have dramatically different structures, the orthologs or family members of several conserved transcription and signaling regulators such as Pax6, Six3, Prox1, and Bmp4 are commonly required for their development. In contrast, our understanding of posttranscriptional regulation in eye development and disease, particularly regarding the function of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010binding proteins (<jats:styled-content style=\"fixed-case\">RBPs<\/jats:styled-content>), is limited. We examine the present knowledge of <jats:styled-content style=\"fixed-case\">RBPs<\/jats:styled-content> in eye development in the insect model <jats:italic>Drosophila<\/jats:italic> as well as several vertebrate models such as fish, frog, chicken, and mouse. Interestingly, of the 42 <jats:styled-content style=\"fixed-case\">RBPs<\/jats:styled-content> that have been investigated for their expression or function in vertebrate eye development, 24 (~60%) are recognized in eukaryotic cells as components of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> granules such as processing bodies, stress granules, or other specialized ribonucleoprotein (<jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content>) complexes. We discuss the distinct developmental and cellular events that may necessitate potential <jats:styled-content style=\"fixed-case\">RBP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> granule\u2010associated <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> regulon models to facilitate posttranscriptional control of gene expression in eye morphogenesis. In support of these hypotheses, three <jats:styled-content style=\"fixed-case\">RBPs<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> granule components Tdrd7, Caprin2, and Stau2 are linked to ocular developmental defects such as congenital cataract, Peters anomaly, and microphthalmia in human patients or animal models. We conclude by discussing the utility of interdisciplinary approaches such as the bioinformatics tool <jats:italic><jats:styled-content style=\"fixed-case\">iSyTE<\/jats:styled-content><\/jats:italic> (integrated Systems Tool for Eye gene discovery) to prioritize <jats:styled-content style=\"fixed-case\">RBPs<\/jats:styled-content> for deriving posttranscriptional regulatory networks in eye development and disease. <jats:italic>WIREs RNA<\/jats:italic> 2016, 7:527\u2013557. doi: 10.1002\/wrna.1355<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules &gt; RNA\u2013Protein Complexes<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Development<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1355","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:58:20Z","timestamp":1462150700000},"page":"527-557","source":"Crossref","is-referenced-by-count":47,"title":["<scp>RNA<\/scp>\u2010binding proteins in eye development and disease: implication of conserved <scp>RNA<\/scp> granule components"],"prefix":"10.1002","volume":"7","author":[{"given":"Soma","family":"Dash","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Delaware  Newark DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana D.","family":"Siddam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Delaware  Newark DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Barnum","sequence":"additional","affiliation":[{"name":"Department of Biological 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