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Flaviviruses are single\u2010stranded, positive\u2010sense\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    viruses, and encode two multidomain proteins,\n                    <jats:styled-content style=\"fixed-case\">NS3<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NS5<\/jats:styled-content>\n                    , that possess all enzymatic activities required for genome replication and capping.\n                    <jats:styled-content style=\"fixed-case\">NS3<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NS5<\/jats:styled-content>\n                    interact within virus\u2010induced replication compartments to form the\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    genome replicase complex. Although the individual enzymatic activities of both proteins have been extensively studied and are well characterized, there are still gaps in our understanding of how they interact to efficiently coordinate their respective activities during positive\u2010strand\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    synthesis and capping. Here, we discuss what is known about the structures and functions of the\n                    <jats:styled-content style=\"fixed-case\">NS3<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NS5<\/jats:styled-content>\n                    proteins and propose a preliminary\n                    <jats:styled-content style=\"fixed-case\">NS3<\/jats:styled-content>\n                    :\n                    <jats:styled-content style=\"fixed-case\">NS5<\/jats:styled-content>\n                    :\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    interaction model based on a large body of literature about how the viral enzymes function, physical restraints between\n                    <jats:styled-content style=\"fixed-case\">NS3<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NS5<\/jats:styled-content>\n                    , as well as critical steps in the replication process.\n                    <jats:italic>WIREs RNA<\/jats:italic>\n                    2017, 8:e1437. doi: 10.1002\/wrna.1437\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"explicit-label\">\n                      <jats:list-item>\n                        <jats:p>RNA Interactions with Proteins and Other Molecules &gt; Protein\u2013RNA Interactions: Functional Implications<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wrna.1437","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T03:10:46Z","timestamp":1502939446000},"source":"Crossref","is-referenced-by-count":69,"title":["Organization of the\n                    <i>Flavivirus<\/i>\n                    <scp>RNA<\/scp>\n                    replicase complex"],"prefix":"10.1002","volume":"8","author":[{"given":"Carolin","family":"Brand","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biochimie, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9 Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bisaillon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie, Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9 Universit\u00e9 de Sherbrooke Sherbrooke QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Geiss","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology Colorado State University Fort Collins CO USA"},{"name":"School of Biomedical Engineering Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"International Committee on Taxonomy of Viruses. 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