{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:04:36Z","timestamp":1790838276546,"version":"4.1.0"},"reference-count":133,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21432002"],"award-info":[{"award-number":["21432002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YFA0505201"],"award-info":[{"award-number":["2017YFA0505201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC0900302"],"award-info":[{"award-number":["2016YFC0900302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs RNA"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p><jats:italic>N<\/jats:italic><jats:sup>6<\/jats:sup>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) is the most abundant internal chemical modification in eukaryotic messenger RNAs (mRNAs). The discovery in 2011 that m<jats:sup>6<\/jats:sup>A is reversed by the fat mass and obesity\u2010associated protein stimulated extensive worldwide research efforts on the regulatory biological functions of dynamic m<jats:sup>6<\/jats:sup>A and other RNA modifications. The epitranscriptomic mark m<jats:sup>6<\/jats:sup>A is written, read, and erased through the activities of a complicated network of enzymes and other proteins. m<jats:sup>6<\/jats:sup>A\u2010binding proteins read m<jats:sup>6<\/jats:sup>A marks and transduce their downstream regulatory effects by altering RNA metabolic processes. In this review, we summarize the current knowledge of m<jats:sup>6<\/jats:sup>A modifications, with particular focus on the functions of its writer, eraser, and reader proteins in posttranscriptional gene regulation and discuss the impact of m<jats:sup>6<\/jats:sup>A marks on human health.<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>RNA Processing &gt; RNA Editing and Modification<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1507","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T15:50:41Z","timestamp":1537890641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Dynamic and reversible RNA <i>N<\/i><sup>6<\/sup>\u2010methyladenosine methylation"],"prefix":"10.1002","volume":"10","author":[{"given":"Hong\u2010Chao","family":"Duan","sequence":"first","affiliation":[{"name":"Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology College of Chemistry and Molecular Engineering, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology College of Chemistry and Molecular Engineering, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Jia","sequence":"additional","affiliation":[{"name":"Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology College of Chemistry and Molecular Engineering, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_12_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045"},{"key":"e_1_2_12_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10324"},{"key":"e_1_2_12_2_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002732"},{"key":"e_1_2_12_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.011"},{"key":"e_1_2_12_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14281"},{"key":"e_1_2_12_2_6_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00833"},{"key":"e_1_2_12_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.021"},{"key":"e_1_2_12_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24678"},{"key":"e_1_2_12_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.019"},{"key":"e_1_2_12_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.002"},{"key":"e_1_2_12_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32497-3"},{"issue":"11","key":"e_1_2_12_2_12_1","first-page":"1233","article-title":"Purification and cDNA cloning of the AdoMet\u2010binding subunit of the human mRNA (N\n                  6\u2010adenosine)\u2010methyltransferase","volume":"3","author":"Bokar J. A.","year":"1997","journal-title":"RNA"},{"key":"e_1_2_12_2_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000910"},{"key":"e_1_2_12_2_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614759113"},{"key":"e_1_2_12_2_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1028"},{"key":"e_1_2_12_2_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.9.4456"},{"key":"e_1_2_12_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3064149"},{"key":"e_1_2_12_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29683"},{"key":"e_1_2_12_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.713"},{"key":"e_1_2_12_2_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf573"},{"key":"e_1_2_12_2_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0607-3"},{"key":"e_1_2_12_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30477-5"},{"key":"e_1_2_12_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.059"},{"key":"e_1_2_12_2_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.3971"},{"key":"e_1_2_12_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00622a021"},{"key":"e_1_2_12_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2048"},{"key":"e_1_2_12_2_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112"},{"key":"e_1_2_12_2_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12626"},{"key":"e_1_2_12_2_29_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00912"},{"key":"e_1_2_12_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07848"},{"key":"e_1_2_12_2_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141634"},{"key":"e_1_2_12_2_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1466"},{"key":"e_1_2_12_2_33_1","unstructured":"Fu Y.(2012).Dynamic regulation of RNA modifications by AlkB family dioxygenases. (PhD thesis). University of Chicago."},{"key":"e_1_2_12_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2822"},{"key":"e_1_2_12_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.026"},{"issue":"5855","key":"e_1_2_12_2_36_1","first-page":"1469","article-title":"The obesity\u2010associated FTO gene encodes a 2\u2010oxoglutarate\u2010dependent nucleic acid demethylase","volume":"318","author":"Gerken T.","year":"2007","journal-title":"Nature"},{"key":"e_1_2_12_2_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1261417"},{"key":"e_1_2_12_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.015"},{"key":"e_1_2_12_2_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07441.x"},{"key":"e_1_2_12_2_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720945115"},{"key":"e_1_2_12_2_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04425.x"},{"key":"e_1_2_12_2_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20577"},{"key":"e_1_2_12_2_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.12.4017"},{"key":"e_1_2_12_2_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241293"},{"key":"e_1_2_12_2_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111577108"},{"key":"e_1_2_12_2_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.500397"},{"key":"e_1_2_12_2_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.99"},{"key":"e_1_2_12_2_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0045-z"},{"key":"e_1_2_12_2_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1276"},{"key":"e_1_2_12_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.003"},{"key":"e_1_2_12_2_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500104"},{"key":"e_1_2_12_2_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.687"},{"key":"e_1_2_12_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.08.019"},{"key":"e_1_2_12_2_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_2_12_2_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.9.2298"},{"key":"e_1_2_12_2_56_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101068"},{"key":"e_1_2_12_2_57_1","doi-asserted-by":"publisher","DOI":"10.1139\/o79-112"},{"key":"e_1_2_12_2_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.309146.117"},{"key":"e_1_2_12_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.005"},{"key":"e_1_2_12_2_60_1","first-page":"xx","article-title":"The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5\u2032\u21923\u2032exoribonuclease XRN1","author":"Kretschmer J.","year":"2018","journal-title":"RNA"},{"key":"e_1_2_12_2_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.20.1.45-53.1976"},{"key":"e_1_2_12_2_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.6.2012"},{"key":"e_1_2_12_2_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509881200"},{"key":"e_1_2_12_2_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20568"},{"key":"e_1_2_12_2_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.10"},{"key":"e_1_2_12_2_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450"},{"key":"e_1_2_12_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.10.019"},{"key":"e_1_2_12_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.11.017"},{"key":"e_1_2_12_2_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.11"},{"key":"e_1_2_12_2_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.10.002"},{"key":"e_1_2_12_2_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.03.021"},{"key":"e_1_2_12_2_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.hmg.a018914"},{"key":"e_1_2_12_2_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1432"},{"key":"e_1_2_12_2_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234"},{"key":"e_1_2_12_2_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx141"},{"key":"e_1_2_12_2_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703139114"},{"key":"e_1_2_12_2_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21022"},{"key":"e_1_2_12_2_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.003"},{"key":"e_1_2_12_2_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3722"},{"key":"e_1_2_12_2_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.3.419"},{"key":"e_1_2_12_2_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3187541"},{"key":"e_1_2_12_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2787(79)90067-4"},{"key":"e_1_2_12_2_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4211(81)90071-7"},{"key":"e_1_2_12_2_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210737200"},{"key":"e_1_2_12_2_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0590-8"},{"key":"e_1_2_12_2_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19342"},{"key":"e_1_2_12_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.003"},{"key":"e_1_2_12_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(74)90153-6"},{"key":"e_1_2_12_2_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.3"},{"key":"e_1_2_12_2_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609041104"},{"key":"e_1_2_12_2_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-007-9059-z"},{"key":"e_1_2_12_2_92_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31311"},{"key":"e_1_2_12_2_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14586"},{"key":"e_1_2_12_2_94_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.064063.117"},{"key":"e_1_2_12_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.047"},{"key":"e_1_2_12_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.048"},{"key":"e_1_2_12_2_97_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00854"},{"key":"e_1_2_12_2_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030115"},{"key":"e_1_2_12_2_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.3.1078"},{"key":"e_1_2_12_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.06.008"},{"key":"e_1_2_12_2_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.15"},{"key":"e_1_2_12_2_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.092"},{"key":"e_1_2_12_2_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.034629"},{"key":"e_1_2_12_2_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006704"},{"key":"e_1_2_12_2_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/3.3.749"},{"key":"e_1_2_12_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33475-0"},{"key":"e_1_2_12_2_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.031"},{"key":"e_1_2_12_2_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4416"},{"key":"e_1_2_12_2_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18298"},{"key":"e_1_2_12_2_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12730"},{"key":"e_1_2_12_2_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.014"},{"key":"e_1_2_12_2_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2902"},{"key":"e_1_2_12_2_113_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744940"},{"key":"e_1_2_12_2_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(75)90158-0"},{"key":"e_1_2_12_2_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.318"},{"key":"e_1_2_12_2_116_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00934"},{"key":"e_1_2_12_2_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.015"},{"key":"e_1_2_12_2_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.021"},{"key":"e_1_2_12_2_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02770-z"},{"key":"e_1_2_12_2_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21671"},{"key":"e_1_2_12_2_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.012"},{"key":"e_1_2_12_2_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515891112"},{"key":"e_1_2_12_2_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808710"},{"key":"e_1_2_12_2_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.003"},{"key":"e_1_2_12_2_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0019-0"},{"key":"e_1_2_12_2_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23883"},{"key":"e_1_2_12_2_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602883113"},{"key":"e_1_2_12_2_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.013"},{"key":"e_1_2_12_2_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21355"},{"key":"e_1_2_12_2_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.151"},{"key":"e_1_2_12_2_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.015"},{"key":"e_1_2_12_2_132_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.108.058883"},{"key":"e_1_2_12_2_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15377"}],"container-title":["WIREs RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwrna.1507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wrna.1507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wrna.1507","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wrna.1507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:14:42Z","timestamp":1693289682000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wrna.1507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":133,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/wrna.1507"],"URL":"https:\/\/doi.org\/10.1002\/wrna.1507","archive":["Portico"],"relation":{},"ISSN":["1757-7004","1757-7012"],"issn-type":[{"value":"1757-7004","type":"print"},{"value":"1757-7012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]},"assertion":[{"value":"2018-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1507"}}