{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:01:11Z","timestamp":1790913671163,"version":"4.1.0"},"reference-count":177,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["SVV\u2010260426"],"award-info":[{"award-number":["SVV\u2010260426"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GA19\u201013491S"],"award-info":[{"award-number":["GA19\u201013491S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs RNA"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stress granules (SGs), hallmarks of the cellular adaptation to stress, promote survival, conserve cellular energy, and are fully dissolved upon the cessation of stress treatment. Different stresses can initiate the assembly of SGs, but arsenite and heat are the best studied of these stresses. The composition of SGs and posttranslational modifications of SG proteins differ depending on the type and severity of the stress insult, methodology used, cell line, and presence of overexpressed and tagged proteins. A group of 18 proteins showing differential localization to SGs in heat\u2010 and arsenite\u2010stressed mammalian cell lines is described. Upon severe and prolonged stress, physiological SGs transform into more solid protein aggregates that are no longer reversible and do not contain mRNA. Similar pathological inclusions are hallmarks of neurodegenerative diseases. SGs induced by heat stress are less dynamic than SGs induced by arsenite and contain a set of unique proteins and linkage\u2010specific polyubiquitinated proteins. The same types of ubiquitin linkages have been found to contribute to the development of neurodegenerative disorders such as Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis (ALS). We propose heat stress\u2010induced SGs as a possible model of an intermediate stage along the transition from dynamic, fully reversible arsenite stress\u2010induced SGs toward aberrant SGs, the hallmark of neurodegenerative diseases. Stress\u2010 and methodology\u2010specific differences in the compositions of SGs and the transition of SGs to aberrant protein aggregates are discussed.<\/jats:p><jats:p>This article is categorized under:<\/jats:p><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><jats:p>RNA Interactions with Proteins and Other Molecules &gt; RNA\u2013Protein Complexes<\/jats:p><jats:p>RNA Export and Localization &gt; RNA Localization<\/jats:p>","DOI":"10.1002\/wrna.1596","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T22:54:20Z","timestamp":1588546460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-4633","authenticated-orcid":false,"given":"Kl\u00e1ra","family":"Frydr\u00fd\u0161kov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-0565","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Ma\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-8911","authenticated-orcid":false,"given":"Martin","family":"Posp\u00ed\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, Faculty of Science Charles University  Prague Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107593"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201600042"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800113"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.16.3227"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.12.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.11.009"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0022-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1791"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.05.052"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07628.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00063"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.199240"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-54"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00423"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.009225"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.6.1151"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.4.11.2437"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328757"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2006.71.038"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.436407"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115791"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.05987-11"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53491-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.037"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.11.020"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2008.00383.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00544-12"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701488114"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0444-0"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.10.010"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.09.058"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.12.020"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6845"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.471"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06383.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.09.017"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-07-0737"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.05.025"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.08.003"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02882"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0141-z"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.06.025"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.033"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077560"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01517-12"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12867-016-0072-x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.12.043"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks566"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.07.021"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-08-0715"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000282"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.045104"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122770"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11497"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00224-06"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1524"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010617"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80330-5"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV118.002809"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90211-9"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800257"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091383"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.001189"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020240"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.09.024"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013325"},{"key":"e_1_2_12_69_1","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. (2012). Arsenic metals fibres and dusts.IARC Monographs on the Evaluation of Carcinogenic Risks to Humans No. 100C(pp. 11\u2013465)."},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17978"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.038"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12125"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1649"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.184614"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1262"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.017"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.131102"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300963"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1877-1173(09)90004-7"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-05-0221"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.6.1257"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.07.004"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201508028"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200502088"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.7.1431"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25767-0"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11922"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035820"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.642900"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06807"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072761"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3394"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.461107"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.033"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00427a031"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.002"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.015"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806372200"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.08.018"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.005443"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.23.7971-7980.2001"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b01162"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06365-0"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.03.015"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.12.022"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.015"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.032"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695957"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12023"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr021"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412882200"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.002"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02309-4"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.02.006"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-10-1061"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0263-4"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2012.76.010637"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.12.008"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.030"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0477-9"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709007"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-12-1120"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1783"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744722"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201609081"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201801214"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.01.019"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4572"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.134551"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.05.004"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.038"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.10.009"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00596-16"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006626"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60596-4"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.2011023"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24395"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0076-9"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300015c"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.9.3354"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-31434-7_8"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05033"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.4.2416"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2018.05.005"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600163"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00511.2008"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.036285"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.019"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00763-12"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32886"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.07.009"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.031"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.12.4357"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(93)90086-E"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212128"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.19"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.739573"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.800706"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1592-12.2012"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.041"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9373"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2019.01.008"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.19.3.1871"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01350-09"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.15.8.4497"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89472-8"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18413"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03119-Z"},{"key":"e_1_2_12_170_1","doi-asserted-by":"crossref","unstructured":"Wilbertz Johannes H. Voigt Franka Horvathova Ivana Roth Gregory Zhan Yinxiu &Chao Jeffrey A.(2018). doi:https:\/\/doi.org\/10.1101\/332502","DOI":"10.1101\/332502"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.033"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0222-5"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.210856"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049267"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403773200"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.025"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39578"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0120-6"}],"container-title":["WIREs RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwrna.1596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wrna.1596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wrna.1596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wrna.1596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:01:22Z","timestamp":1693198882000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wrna.1596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,3]]},"references-count":177,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/wrna.1596"],"URL":"https:\/\/doi.org\/10.1002\/wrna.1596","archive":["Portico"],"relation":{},"ISSN":["1757-7004","1757-7012"],"issn-type":[{"value":"1757-7004","type":"print"},{"value":"1757-7012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,3]]},"assertion":[{"value":"2019-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1596"}}