{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:02:22Z","timestamp":1790953342854,"version":"4.1.0"},"reference-count":185,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS075367"],"award-info":[{"award-number":["R01NS075367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wires.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["WIREs RNA"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Like all other parts of the central nervous system, the mammalian neocortex undergoes temporally ordered set of developmental events, including proliferation, differentiation, migration, cellular identity, synaptogenesis, connectivity formation, and plasticity changes. These neurodevelopmental mechanisms have been characterized by studies focused on transcriptional control. Recent findings, however, have shown that the spatiotemporal regulation of post\u2010transcriptional steps like alternative splicing, mRNA traffic\/localization, mRNA stability\/decay, and finally repression\/derepression of protein synthesis (mRNA translation) have become just as central to the neurodevelopment as transcriptional control. A number of dynamic players act post\u2010transcriptionally in the neocortex to regulate these steps, as RNA binding proteins (RBPs), ribosomal proteins (RPs), long non\u2010coding RNAs, and\/or microRNA. Remarkably, mutations in these post\u2010transcriptional regulators have been associated with neurodevelopmental, neurodegenerative, inherited, or often co\u2010morbid disorders, such as microcephaly, autism, epilepsy, intellectual disability, white matter diseases, Rett\u2010syndrome like phenotype, spinocerebellar ataxia, and amyotrophic lateral sclerosis. Here, we focus on the current state, advanced methodologies and pitfalls of this exciting and upcoming field of RNA metabolism with vast potential in understanding fundamental neurodevelopmental processes and pathologies.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Translation &gt; Translation Regulation<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules &gt; Protein\u2010RNA Interactions: Functional Implications<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1674","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T12:01:06Z","timestamp":1623931266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Making sense of <scp>mRNA<\/scp> landscapes: Translation control in neurodevelopment"],"prefix":"10.1002","volume":"13","author":[{"given":"Yongkyu","family":"Park","sequence":"first","affiliation":[{"name":"RWJ Medical School Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Page","sequence":"additional","affiliation":[{"name":"RWJ Medical School Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Salamon","sequence":"additional","affiliation":[{"name":"RWJ Medical School Rutgers University  New Brunswick New Jersey 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