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Numerous studies have focused on the identification of host factors and cellular pathways involved in the viral replication cycle. The speed and magnitude of hijacking the translation machinery of host mRNA, and shutting down host transcription are still not well understood. Since SARS\u2010CoV\u20102 relies on host RNA\u2010binding proteins for the infection progression, several efforts have been made to define the SARS\u2010CoV\u20102 RNA\u2010bound proteomes (RNA\u2013protein interactomes). Methodologies that enable the systemic capture of protein interactors of given RNA in vivo have been adapted for the identification of the SARS\u2010CoV\u20102 RNA interactome. The obtained proteomic data aided by genome\u2010wide and targeted CRISPR perturbation screens, revealed host factors with either pro\u2010 or anti\u2010viral activity and highlighted cellular processes and factors involved in host response. We focus here on the recent studies on SARS\u2010CoV\u20102 RNA\u2013protein interactomes, with regard to both the technological aspects of RNA interactome capture methods and the obtained results. We also summarize several related studies, which were used in the interpretation of the SARS\u2010CoV\u20102 RNA\u2013protein interactomes. These studies provided the selection of host factors that are potentially suitable candidates for antiviral therapy. Finally, we underscore the importance of RNA\u2013protein interactome studies in regard to the effective development of antiviral strategies against current and future threats.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules &gt; Protein\u2010RNA Interactions: Functional Implications<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Methods &gt; RNA Analyses in Cells<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1727","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T01:08:39Z","timestamp":1648429719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RNA\u2013protein interactomes as invaluable resources to study RNA viruses: Insights from SARS CoV\u20102 studies"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-4318","authenticated-orcid":false,"given":"Marcin","family":"Koli\u0144ski","sequence":"first","affiliation":[{"name":"Department of Non\u2010Coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-3232","authenticated-orcid":false,"given":"Ewelina","family":"Ka\u0142u\u017cna","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-6577","authenticated-orcid":false,"given":"Monika","family":"Piwecka","sequence":"additional","affiliation":[{"name":"Department of Non\u2010Coding RNAs Institute of Bioorganic Chemistry, Polish 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