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These conditions manifest as disease spectra, progressing from benign hepatic steatosis to symptomatic steatohepatitis, cirrhosis, and, ultimately, hepatocellular carcinoma. With numerous intricately regulated molecular pathways implicated in its pathophysiology, recent data have emphasized the critical roles of RNA\u2010binding proteins (RBPs) in the onset and development of FLD. They regulate gene transcription and post\u2010transcriptional processes, including pre\u2010mRNA splicing, capping, and polyadenylation, as well as mature mRNA transport, stability, and translation. RBP dysfunction at every point along the mRNA life cycle has been associated with altered lipid metabolism and cellular stress response, resulting in hepatic inflammation and fibrosis. Here, we discuss the current understanding of the role of RBPs in the post\u2010transcriptional processes associated with FLD and highlight the possible and emerging therapeutic strategies leveraging RBP function for FLD treatment.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1840","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T06:33:20Z","timestamp":1712990000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Emerging roles of <scp>RNA\u2010binding<\/scp> proteins in fatty liver disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Oluwafolajimi","family":"Adesanya","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diptatanu","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-0006","authenticated-orcid":false,"given":"Auinash","family":"Kalsotra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Cancer Center University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Carl R. 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