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Many studies prove that <jats:italic>LINC00152<\/jats:italic> influences the progression of various tumors via promoting the tumor cells malignant phenotype, chemoresistance, and immune escape. <jats:italic>LINC00152<\/jats:italic> is regulated by multiple transcription factors and DNA hypomethylation. In addition, <jats:italic>LINC00152<\/jats:italic> participates in the regulation of complex molecular signaling networks through epigenetic regulation, protein interactions, and competitive endogenous RNA (ceRNA). Here, we provide a systematic review of the upstream regulatory factors of <jats:italic>LINC00152<\/jats:italic> expression level in different types of tumors. In addition, we revisit the main functions and mechanisms of <jats:italic>LINC00152<\/jats:italic> as driver oncogene and biomarker in pan\u2010cancer.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Methods &gt; RNA Analyses in Cells<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules &gt; RNA\u2010Protein Complexes<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.1851","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T06:46:06Z","timestamp":1714805166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp><i>LINC00152<\/i><\/scp>: Potential driver oncogene in 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