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Here, we focus on two major RNA modifications, one on rRNA (2\u2032O Methylation) and another on mRNA (N<jats:sup>6<\/jats:sup>\u2010Methyladenosine [m<jats:sup>6<\/jats:sup>A]) and their impact on translation. The 2\u2032O methyl group addition on the ribose sugar of rRNA plays a critical role in RNA folding, ribosome assembly, and its interaction with many RNA binding proteins. Differential methylation of these sites contributes to ribosome heterogeneity and generates potential \u201cspecialized ribosomes.\u201d Specialized ribosomes are proposed to play a variety of important roles in maintaining pluripotency, lineage specification, and compartmentalized and activity\u2010mediated translation in neurons. The m<jats:sup>6<\/jats:sup>A modification, on the other hand, determines the stability, transport, and translation of subclasses of mRNA. The dynamic nature of m<jats:sup>6<\/jats:sup>A owing to the localization and activity of its writers, readers, and erasers makes it a powerful tool for spatiotemporal regulation of translation. While substantial information has accumulated on the nature and abundance of these modifications, their functional consequences are still understudied. In this article, we review the literature constructing the body of our understanding of these two modifications and their outcome on the regulation of translation in general and their impact on the nervous system in particular. We also explore the possibility of how these modifications may collaborate in modulating translation and provoke the thought to integrate the functions of multiple epitranscriptome modifications.<\/jats:p>","DOI":"10.1002\/wrna.70004","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:08:37Z","timestamp":1739876917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epitranscriptome\u2010Mediated Regulation of\u00a0Neuronal Translation"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9682-0400","authenticated-orcid":false,"given":"Syed Wasifa","family":"Qadri","sequence":"first","affiliation":[{"name":"Centre for Brain Research Indian Institute of Science  Bangalore India"},{"name":"Manipal Academy of Higher Education (MAHE)  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0383-4262","authenticated-orcid":false,"given":"Nisa Manzoor","family":"Shah","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Indian Institute of Science  Bangalore India"},{"name":"Manipal Academy of Higher Education (MAHE)  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-6194","authenticated-orcid":false,"given":"Ravi S.","family":"Muddashetty","sequence":"additional","affiliation":[{"name":"Centre for Brain Research Indian Institute of Science  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010023\u201002602\u2010z"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb905"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.011"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa002"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506749112"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213851"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.155283"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100995"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408362"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111317"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201019699\u2010y"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/190576a0"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089640"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.041848"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3120163"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1083"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2204933120"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250426397"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2022.12.010"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170166"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1162607"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100361\u2010y"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100538\u20108"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3148"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010018\u20100030\u2010z"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.02.024"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf573"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx525"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15711.1"},{"issue":"4","key":"e_1_2_16_31_1","first-page":"928","article-title":"Autism or Atypical Autism in Maternally but Not Paternally Derived Proximal 15q Duplication","volume":"60","author":"Cook E. 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