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Our recent observation of spatiotemporal regulation of cell surface ribonucleoproteins, consisting of glycoRNA and RNA\u2010binding proteins, by heparan sulfate expands this knowledge to the extracellular matrix (ECM). We identified VEGF\u2010A as a new noncanonical cell surface RNA\u2010binding protein through the arginine residues within the heparan sulfate binding domain. The interaction between VEGF\u2010A and cell surface RNA as a polyanion in the ECM provides an expanded example of the cell surface RNA interactome. 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