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Pathogenic variations in genes that code for PARN and telomerase complex enzymes have been implicated in several rare genetic diseases, including bone marrow failure syndromes, telomere biology\u2010related disorders, and neoplastic ailments. This is further exemplified by defects in p53 signaling, which not only exacerbate the effects of telomere shortening but also negatively regulate PARN activity, thereby promoting cancer development and accelerated aging. This review examines the molecular interactions between PARN and telomerase, as well as their implications in disease development, with a focus on emerging therapeutic strategies that target the pathways regulated by these two enzymes.<\/jats:p>","DOI":"10.1002\/wrna.70049","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:36:02Z","timestamp":1782264962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Interplay of\n                    <scp>PARN<\/scp>\n                    and Telomerase: Tail Modifiers and Disease Implications"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8585-4596","authenticated-orcid":false,"given":"Sujitha","family":"Felicitus","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalon Suzanne","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Samanvitha","family":"Madagundapalli Ramakrishna","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechamma Pandyanada","family":"Nanjappa","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunimala","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-6576","authenticated-orcid":false,"given":"Anirban","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cancer Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER)  Mangalore India"},{"name":"Department of Medical Oncology Nitte (Deemed to be University), KS Hegde Medical Academy  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.14844"},{"key":"e_1_2_11_3_1","first-page":"16","article-title":"Expression of Poly (A)\u2010specific Ribonuclease in Solid Tumours and Haematopoietic Malignancies","volume":"15","author":"Babu N. 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