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This process, termed pre\u2010mRNA splicing, is carried out by a spliceosome, a dynamic RNA\u2010protein macromolecular machinery. Proteomic studies have shown that many spliceosomal components and associated factors harbor protein arginine methylation, a type of post\u2010translational modification. These findings raise the question of how arginine methylation influences the process or outcome of pre\u2010mRNA splicing. Although targeted studies have provided important molecular insights into how this modification regulates splicing protein subcellular localization, abundance, RNA\/protein interactions, and snRNP biogenesis, much remains unknown, especially given the large number of methylated proteins identified that have known roles in regulating pre\u2010mRNA splicing. 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