{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:27:12Z","timestamp":1791026832827,"version":"4.1.0"},"reference-count":220,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs RNA"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ribonucleoprotein (RNP) complexes function in nearly every facet of cellular activity. The spliceosome is an essential RNP that accurately identifies introns and catalytically removes the intervening sequences, providing exquisite control of spatial, temporal, and developmental gene expressions. U\u2010snRNPs are the building blocks for the spliceosome. A significant amount of insight into the molecular assembly of these essential particles has recently come from a seemingly unexpected area of research: neurodegeneration. Survival motor neuron (SMN) performs an essential role in the maturation of snRNPs, while the homozygous loss of SMN1 results in the development of spinal muscular atrophy (SMA), a devastating neurodegenerative disease. In this review, the function of SMN is examined within the context of snRNP biogenesis and evidence is examined which suggests that the SMN functional defects in snRNP biogenesis may account for the motor neuron pathology observed in SMA. <jats:italic>WIREs RNA<\/jats:italic> 2011 2 546\u2013564 DOI: 10.1002\/wrna.76<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules &gt; RNA\u2013Protein Complexes<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA Processing &gt; Processing of Small RNAs<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RNA in Disease and Development &gt; RNA in Disease<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wrna.76","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T17:03:29Z","timestamp":1297962209000},"page":"546-564","source":"Crossref","is-referenced-by-count":67,"title":["SMN in spinal muscular atrophy and snRNP biogenesis"],"prefix":"10.1002","volume":"2","author":[{"given":"Tristan H.","family":"Coady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Lorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,17]]},"reference":[{"key":"e_1_2_4_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"e_1_2_4_1_3_1","first-page":"289","volume":"48","author":"Rossoll W","year":"2009","journal-title":"Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes Results Probl Cell Differ"},{"key":"e_1_2_4_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.02.004"},{"key":"e_1_2_4_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"e_1_2_4_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.06.008"},{"key":"e_1_2_4_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi390"},{"key":"e_1_2_4_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"e_1_2_4_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.8.1205"},{"key":"e_1_2_4_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00725.x"},{"key":"e_1_2_4_3_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.4.715"},{"key":"e_1_2_4_3_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/301992"},{"key":"e_1_2_4_3_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5186"},{"key":"e_1_2_4_3_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4858"},{"key":"e_1_2_4_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2124"},{"key":"e_1_2_4_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00332-0"},{"key":"e_1_2_4_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400941"},{"key":"e_1_2_4_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/338627"},{"key":"e_1_2_4_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90847-8"},{"key":"e_1_2_4_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ef6079"},{"key":"e_1_2_4_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2010.03.001"},{"key":"e_1_2_4_3_19_2","first-page":"415","article-title":"Preserved umbilical cord facilitates antenatal diagnosis of spinal muscular atrophy.","volume":"40","author":"Kabra M","year":"2003","journal-title":"Indian Pediatr"},{"key":"e_1_2_4_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2008.04.006"},{"key":"e_1_2_4_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.08.007"},{"key":"e_1_2_4_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305665"},{"key":"e_1_2_4_3_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000290830.40544.b9"},{"key":"e_1_2_4_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20473"},{"key":"e_1_2_4_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540290108025"},{"key":"e_1_2_4_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90461-1"},{"key":"e_1_2_4_3_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/bmme.1997.2590"},{"key":"e_1_2_4_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6307"},{"key":"e_1_2_4_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1177"},{"key":"e_1_2_4_3_30_2","first-page":"1057","article-title":"Hybrid survival motor neuron genes in patients with autosomal recessive spinal muscular atrophy: new insights into molecular mechanisms responsible for the disease.","volume":"59","author":"Hahnen E","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.12.001"},{"key":"e_1_2_4_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0095-5"},{"key":"e_1_2_4_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9920"},{"key":"e_1_2_4_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390100473"},{"key":"e_1_2_4_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.3.1705"},{"key":"e_1_2_4_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/71709"},{"key":"e_1_2_4_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.16.2451"},{"key":"e_1_2_4_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.3.333"},{"key":"e_1_2_4_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01262-08"},{"key":"e_1_2_4_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.2.259"},{"key":"e_1_2_4_3_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652409789105516"},{"key":"e_1_2_4_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.08.055"},{"key":"e_1_2_4_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq147"},{"key":"e_1_2_4_3_44_2","first-page":"3","article-title":"Spinal muscular atrophy disease: a literature review for therapeutic strategies.","volume":"3","author":"Stavarachi M","year":"2010","journal-title":"J Med Life"},{"key":"e_1_2_4_3_45_2","doi-asserted-by":"publisher","DOI":"10.2741\/3670"},{"key":"e_1_2_4_3_46_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.4.1.4535"},{"key":"e_1_2_4_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160181697"},{"key":"e_1_2_4_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng854"},{"key":"e_1_2_4_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq343"},{"key":"e_1_2_4_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.4.1333-1346.2006"},{"key":"e_1_2_4_3_51_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.7580704"},{"key":"e_1_2_4_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.01.067"},{"key":"e_1_2_4_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1207"},{"key":"e_1_2_4_3_54_2","first-page":"108","article-title":"Splicing therapeutics in SMN2 and APOB.","volume":"11","author":"Khoo B","year":"2009","journal-title":"Curr Opin Mol Ther"},{"key":"e_1_2_4_3_55_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-540-34449-0_6","article-title":"Spinal muscular atrophy and therapeutic prospects.","volume":"44","author":"Wirth B","year":"2006","journal-title":"Prog Mol Subcell Biol"},{"key":"e_1_2_4_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.01.012"},{"key":"e_1_2_4_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp076"},{"key":"e_1_2_4_3_58_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003468"},{"key":"e_1_2_4_3_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4489-09.2010"},{"key":"e_1_2_4_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300222"},{"key":"e_1_2_4_3_61_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.067"},{"key":"e_1_2_4_3_62_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1941310"},{"key":"e_1_2_4_3_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050073"},{"key":"e_1_2_4_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.01.014"},{"key":"e_1_2_4_3_65_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107632200"},{"key":"e_1_2_4_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.08.022"},{"key":"e_1_2_4_3_67_2","doi-asserted-by":"crossref","unstructured":"MarquisJ MeyerK AngehrnL KampferSS Rothen\u2010RutishauserB SchumperliD.Spinal muscular atrophy: SMN2 pre\u2010mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence.Mol Ther2007 15:1479\u20131486(Epub ahead of print; June 5 2007).","DOI":"10.1038\/sj.mt.6300200"},{"key":"e_1_2_4_3_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn382"},{"key":"e_1_2_4_3_69_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.6.3.8723"},{"key":"e_1_2_4_3_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0633863100"},{"key":"e_1_2_4_3_71_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0950-09.2009"},{"key":"e_1_2_4_3_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008204"},{"key":"e_1_2_4_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-265"},{"key":"e_1_2_4_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80368-2"},{"key":"e_1_2_4_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80367-0"},{"key":"e_1_2_4_3_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-945"},{"key":"e_1_2_4_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)02371-1"},{"key":"e_1_2_4_3_78_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809031200"},{"key":"e_1_2_4_3_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11167"},{"key":"e_1_2_4_3_80_2","first-page":"13.","article-title":"Identification and characterization of Gemin7, a novel component of the SMN complex.","volume":"13","author":"Baccon J","year":"2002","journal-title":"J Biol Chem"},{"key":"e_1_2_4_3_81_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512243200"},{"key":"e_1_2_4_3_82_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.6.1181"},{"key":"e_1_2_4_3_83_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.6.1177"},{"key":"e_1_2_4_3_84_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109448200"},{"key":"e_1_2_4_3_85_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110141200"},{"key":"e_1_2_4_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.03.034"},{"key":"e_1_2_4_3_87_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608528200"},{"key":"e_1_2_4_3_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-63"},{"key":"e_1_2_4_3_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.1.93"},{"key":"e_1_2_4_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.06.058"},{"key":"e_1_2_4_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.05.139"},{"key":"e_1_2_4_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.158"},{"key":"e_1_2_4_3_93_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3967-05.2006"},{"key":"e_1_2_4_3_94_2","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.23-16-06627.2003","article-title":"Active transport of the survival motor neuron protein and the role of exon\u20107 in cytoplasmic localization.","volume":"23","author":"Zhang HL","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_4_3_95_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003299200"},{"key":"e_1_2_4_3_96_2","doi-asserted-by":"publisher","DOI":"10.1017\/S135583820101442X"},{"key":"e_1_2_4_3_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.15.1785"},{"key":"e_1_2_4_3_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.embor863"},{"key":"e_1_2_4_3_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.53.37908"},{"key":"e_1_2_4_3_100_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155085"},{"key":"e_1_2_4_3_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5443"},{"key":"e_1_2_4_3_102_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707304200"},{"key":"e_1_2_4_3_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm327"},{"key":"e_1_2_4_3_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.17.3595"},{"key":"e_1_2_4_3_105_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.1.75"},{"key":"e_1_2_4_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.084"},{"key":"e_1_2_4_3_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.9.1017"},{"key":"e_1_2_4_3_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20869"},{"key":"e_1_2_4_3_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.07.010"},{"key":"e_1_2_4_3_110_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212483099"},{"key":"e_1_2_4_3_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104207200"},{"key":"e_1_2_4_3_112_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.908401"},{"key":"e_1_2_4_3_113_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309218200"},{"key":"e_1_2_4_3_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2003.08.011"},{"key":"e_1_2_4_3_115_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1219"},{"key":"e_1_2_4_3_116_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.5008-5013.2003"},{"key":"e_1_2_4_3_117_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.12.6364-6369.2002"},{"key":"e_1_2_4_3_118_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.8.3892-3904.2002"},{"key":"e_1_2_4_3_119_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108769200"},{"key":"e_1_2_4_3_120_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100233200"},{"key":"e_1_2_4_3_121_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805092"},{"key":"e_1_2_4_3_122_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00409"},{"key":"e_1_2_4_3_123_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206056200"},{"key":"e_1_2_4_3_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/35070059"},{"key":"e_1_2_4_3_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.029"},{"key":"e_1_2_4_3_126_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20111"},{"key":"e_1_2_4_3_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200003)15:3<228::AID-HUMU3>3.0.CO;2-9"},{"key":"e_1_2_4_3_128_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.775"},{"key":"e_1_2_4_3_129_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.8.1269"},{"key":"e_1_2_4_3_130_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2869"},{"key":"e_1_2_4_3_131_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2351"},{"key":"e_1_2_4_3_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200346"},{"key":"e_1_2_4_3_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/83014"},{"key":"e_1_2_4_3_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00148-7"},{"key":"e_1_2_4_3_135_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902021406"},{"key":"e_1_2_4_3_136_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0024-5"},{"key":"e_1_2_4_3_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.05.014"},{"key":"e_1_2_4_3_138_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.3.497"},{"key":"e_1_2_4_3_139_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm192"},{"key":"e_1_2_4_3_140_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4300-z"},{"key":"e_1_2_4_3_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.06.059"},{"key":"e_1_2_4_3_142_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070399"},{"key":"e_1_2_4_3_143_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi131"},{"key":"e_1_2_4_3_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21308"},{"key":"e_1_2_4_3_145_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807305669"},{"key":"e_1_2_4_3_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81632-3"},{"key":"e_1_2_4_3_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00211-8"},{"key":"e_1_2_4_3_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90021-6"},{"key":"e_1_2_4_3_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90292-M"},{"key":"e_1_2_4_3_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90436-0"},{"key":"e_1_2_4_3_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80371-2"},{"key":"e_1_2_4_3_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/376709a0"},{"key":"e_1_2_4_3_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90530-4"},{"key":"e_1_2_4_3_154_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1995.060.01.072"},{"key":"e_1_2_4_3_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81666-9"},{"key":"e_1_2_4_3_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80829-6"},{"key":"e_1_2_4_3_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.07.025"},{"key":"e_1_2_4_3_158_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.19.3861"},{"key":"e_1_2_4_3_159_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00579.x"},{"key":"e_1_2_4_3_160_2","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1002\/j.1460-2075.1989.tb08563.x","article-title":"Cloned human snRNP proteins B and B\u2032 differ only in their carboxy\u2010terminal part.","volume":"8","author":"van Dam A","year":"1989","journal-title":"EMBO J"},{"key":"e_1_2_4_3_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00244-1"},{"key":"e_1_2_4_3_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00592-9"},{"key":"e_1_2_4_3_163_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf585"},{"key":"e_1_2_4_3_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.020"},{"key":"e_1_2_4_3_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.03.009"},{"key":"e_1_2_4_3_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.03.022"},{"key":"e_1_2_4_3_167_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074962"},{"key":"e_1_2_4_3_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(99)80032-3"},{"key":"e_1_2_4_3_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80550-4"},{"key":"e_1_2_4_3_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.03.014"},{"key":"e_1_2_4_3_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2009.12.003"},{"key":"e_1_2_4_3_172_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1584"},{"key":"e_1_2_4_3_173_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.molcel.2010.03.014","article-title":"Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis.","volume":"38","author":"Yong J","journal-title":"Mol Cell"},{"key":"e_1_2_4_3_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00484-7"},{"key":"e_1_2_4_3_175_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.22.6783"},{"key":"e_1_2_4_3_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90181-7"},{"key":"e_1_2_4_3_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.03.005"},{"key":"e_1_2_4_3_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80052-0"},{"key":"e_1_2_4_3_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80475-8"},{"key":"e_1_2_4_3_180_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01308"},{"key":"e_1_2_4_3_181_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600296"},{"key":"e_1_2_4_3_182_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405160"},{"key":"e_1_2_4_3_183_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210087"},{"key":"e_1_2_4_3_184_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1259"},{"key":"e_1_2_4_3_185_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2005.084"},{"key":"e_1_2_4_3_186_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.16.4536"},{"key":"e_1_2_4_3_187_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1377"},{"key":"e_1_2_4_3_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80016-7"},{"key":"e_1_2_4_3_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80479-1"},{"key":"e_1_2_4_3_190_2","first-page":"586","article-title":"Splicing of a divergent subclass of AT\u2010AC introns requires the major spliceosomal snRNAs.","volume":"3","author":"Wu Q","year":"1997","journal-title":"RNA"},{"key":"e_1_2_4_3_191_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000921"},{"key":"e_1_2_4_3_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.031"},{"key":"e_1_2_4_3_193_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000773"},{"key":"e_1_2_4_3_194_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq300"},{"key":"e_1_2_4_3_195_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-10-16"},{"key":"e_1_2_4_3_196_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq329"},{"key":"e_1_2_4_3_197_2","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddq340","article-title":"SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.","author":"Wishart TM","year":"2010","journal-title":"Hum Mol Genet"},{"key":"e_1_2_4_3_198_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.5.3225"},{"key":"e_1_2_4_3_199_2","doi-asserted-by":"publisher","DOI":"10.1007\/400_2009_4"},{"key":"e_1_2_4_3_200_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.14.1605"},{"key":"e_1_2_4_3_201_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200304128"},{"key":"e_1_2_4_3_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01320-X"},{"key":"e_1_2_4_3_203_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-32-10433.2003"},{"key":"e_1_2_4_3_204_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10313"},{"key":"e_1_2_4_3_205_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00972-07"},{"key":"e_1_2_4_3_206_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03251.2003"},{"key":"e_1_2_4_3_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00357-9"},{"key":"e_1_2_4_3_208_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq073"},{"key":"e_1_2_4_3_209_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp310"},{"key":"e_1_2_4_3_210_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200303168"},{"key":"e_1_2_4_3_211_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn189"},{"key":"e_1_2_4_3_212_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp506"},{"key":"e_1_2_4_3_213_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.342005"},{"key":"e_1_2_4_3_214_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6849"},{"key":"e_1_2_4_3_215_2","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1016\/S0021-9258(19)52543-1","article-title":"F\u2010actin binding and bundling properties of fimbrin, a major cytoskeletal protein of microvillus core filaments.","volume":"256","author":"Glenney JR","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_4_3_216_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.05.009"},{"key":"e_1_2_4_3_217_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq021"},{"key":"e_1_2_4_3_218_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp157"}],"container-title":["WIREs RNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwrna.76","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fwrna.76","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wrna.76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:50:28Z","timestamp":1695685828000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wrna.76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,17]]},"references-count":220,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1002\/wrna.76"],"URL":"https:\/\/doi.org\/10.1002\/wrna.76","archive":["Portico"],"relation":{},"ISSN":["1757-7004","1757-7012"],"issn-type":[{"value":"1757-7004","type":"print"},{"value":"1757-7012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,17]]}}}