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This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the \u2018cyst\u2010ems biology\u2019 of polycystic kidney disease. <jats:italic>WIREs Syst Biol Med<\/jats:italic> 2015, 7:39\u201352. doi: 10.1002\/wsbm.1289<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Analytical and Computational Methods &gt; Computational Methods<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Laboratory Methods and Technologies &gt; Genetic\/Genomic Methods<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Translational, Genomic, and Systems Medicine &gt; Translational Medicine<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1289","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T11:28:54Z","timestamp":1422876534000},"page":"39-52","source":"Crossref","is-referenced-by-count":20,"title":["Systems biology of polycystic kidney disease: a critical 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