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Skeletal muscle can be viewed as a biomechanical device with various interacting components including the autonomic nerves for impulse transmission, vasculature for efficient oxygenation, and embedded regulatory and metabolic machinery for maintaining cellular homeostasis. The \u201comics\u201d revolution has propelled a new era in muscle research, allowing us to discern minute details of molecular cross\u2010talk required for effective coordination between the myriad interacting components for efficient muscle function. The objective of this review is to provide a systems\u2010level, comprehensive mapping the molecular mechanisms underlying skeletal muscle structure and function, in health and disease. We begin this review with a focus on molecular mechanisms underlying muscle tissue development (myogenesis), with an emphasis on satellite cells and muscle regeneration. We next review the molecular structure and mechanisms underlying the many structural components of the muscle: neuromuscular junction, sarcomere, cytoskeleton, extracellular matrix, and vasculature surrounding muscle. We highlight aberrant molecular mechanisms and their possible clinical or pathophysiological relevance. We particularly emphasize the impact of environmental stressors (inflammation and oxidative stress) in contributing to muscle pathophysiology including atrophy, hypertrophy, and fibrosis.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Physiology &gt; Mammalian Physiology in Health and Disease<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Developmental Biology &gt; Developmental Processes in Health and Disease<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Models of Systems Properties and Processes &gt; Cellular Models<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wsbm.1462","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T05:56:24Z","timestamp":1565675784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":626,"title":["Skeletal muscle: A review of molecular structure and function, in health and disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-2315","authenticated-orcid":false,"given":"Kavitha","family":"Mukund","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of California  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-4659","authenticated-orcid":false,"given":"Shankar","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Bioinformatics &amp; Systems Biology University of California  San Diego California"},{"name":"Department of Computer Science and Engineering University of California  San Diego California"},{"name":"Department of Cellular and Molecular Medicine and Nanoengineering University of California  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_18_1_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00268-06"},{"key":"e_1_2_18_2_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.5.10851"},{"key":"e_1_2_18_2_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540434"},{"key":"e_1_2_18_2_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00391"},{"key":"e_1_2_18_2_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.085159"},{"key":"e_1_2_18_2_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153305"},{"key":"e_1_2_18_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08889"},{"key":"e_1_2_18_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041380213"},{"key":"e_1_2_18_2_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.7"},{"key":"e_1_2_18_2_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131445"},{"key":"e_1_2_18_2_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811129106"},{"key":"e_1_2_18_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.009"},{"key":"e_1_2_18_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3520"},{"key":"e_1_2_18_2_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.3.735"},{"key":"e_1_2_18_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn801"},{"key":"e_1_2_18_2_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070075"},{"key":"e_1_2_18_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2618"},{"key":"e_1_2_18_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.03.005"},{"key":"e_1_2_18_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.08.007"},{"key":"e_1_2_18_2_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-01-00153.1990"},{"key":"e_1_2_18_2_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0763"},{"key":"e_1_2_18_2_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00263.x"},{"key":"e_1_2_18_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm884"},{"key":"e_1_2_18_2_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205866200"},{"key":"e_1_2_18_2_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08456.2001"},{"key":"e_1_2_18_2_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12214"},{"key":"e_1_2_18_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.018"},{"key":"e_1_2_18_2_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.187831"},{"key":"e_1_2_18_2_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0243-8"},{"key":"e_1_2_18_2_30_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100842"},{"key":"e_1_2_18_2_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/960363"},{"key":"e_1_2_18_2_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/905612"},{"issue":"3","key":"e_1_2_18_2_33_1","first-page":"575","article-title":"Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers","volume":"4","author":"Ban C. 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