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Many species of animals as well as humans have evolved various physiological mechanisms for body temperature control, which are characteristically flexible and enable a fine\u2010tuned spatial and temporal regulation of body temperature in different environmental conditions and circumstances. Human beings normally maintain a core body temperature at around 37\u00b0C, and maintenance of this relatively high temperature is critical for survival. Therefore, principles of thermoregulatory control have also important clinical implications. Infections can cause the body temperature to rise internally and several diseases can cause a dysfunction of thermoregulatory mechanisms. Moreover, the utilization of thermotherapies in treating various diseases has been known for thousands of years with a recent resurgence of interest. An increasing amount of research suggests that targeted temperature management is of paramount importance to patient outcomes in certain clinical scenarios. We provide a concise summary of the basic concepts of thermoregulation. Emphasis is given to the principles of thermoregulation in humans in basic pathological states and to targeted temperature management strategies in the clinical environment, with special attention on therapeutic hypothermia in postcardiac arrest patients. Finally, the discussion is focused on the potential offered by computational thermophysiological models for predicting thermal responses of patients in various clinical circumstances, for proposing new perspectives in the design of novel thermal therapies, and to optimize targeted temperature management strategies.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Cardiovascular Diseases &gt; Computational Models<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cardiovascular Diseases &gt; Environmental Factors<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cardiovascular Diseases &gt; Biomedical Engineering<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1513","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T21:13:02Z","timestamp":1623359582000},"source":"Crossref","is-referenced-by-count":16,"title":["Thermoregulation: A journey from physiology to 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