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Over the past few decades, the model organism\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    has been crucial in identifying cancer\u2010related genes and pathways and elucidating mechanisms underlying growth regulation in development. Investigations using\n                    <jats:italic>Drosophila<\/jats:italic>\n                    has yielded new insights into the molecular mechanisms involved in tumor initiation and progression. In this review, we describe various tumor models that have been developed in recent years using different\n                    <jats:italic>Drosophila<\/jats:italic>\n                    tissues, such as the imaginal tissue, the neural tissue, the gut, the ovary, and hematopoietic cells. We discuss underlying genetic alterations, cancer\u2010like characteristics, as well as similarities and key differences among these models. We also discuss how disruptions in stem cell division and differentiation result in tumor formation in diverse tissues, and highlight new concepts developed using the fly model to understand context\u2010dependent tumorigenesis. We further discuss the progress made in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    to explore tumor\u2013host interactions that involve the innate immune response to tumor growth and the cachexia wasting phenotype.\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Cancer &gt; Genetics\/Genomics\/Epigenetics<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Cancer &gt; Stem Cells and Development<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Cancer &gt; Molecular and Cellular Physiology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  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