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The canonical FGFs, endocrine FGFs, and iFGFs have been reviewed extensively by us and others. In this review, we briefly summarize past reviews and then focus on new developments in the FGF field since our last review in 2015. Some of the highlights in the past 6\u2009years include the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, an expanded understanding of endocrine FGF signaling, functions for FGF signaling in stem cell pluripotency and differentiation, roles for FGF signaling in tissue homeostasis and regeneration, a continuing elaboration of mechanisms of FGF signaling in development, and an expanding appreciation of roles for FGF signaling in neuropsychiatric diseases.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Cardiovascular Diseases &gt; Molecular and Cellular Physiology<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Neurological Diseases &gt; Molecular and Cellular Physiology<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Congenital Diseases &gt; Stem Cells and Development<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cancer &gt; Stem Cells and Development<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1549","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T07:16:07Z","timestamp":1644477367000},"source":"Crossref","is-referenced-by-count":131,"title":["New developments in the biology of fibroblast growth factors"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-7629","authenticated-orcid":false,"given":"David M.","family":"Ornitz","sequence":"first","affiliation":[{"name":"Department of Developmental Biology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Pharmaceutical Sciences  Sakyo Kyoto 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